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ProteomicsNATCANCER-A16341B 1 2 iNV GOV 3 4GOV
Oncolytic viruses (OVs) are replication-competent viruses that selectively infect tumor cells and induce anti-tumor responses. However, systemic delivery is limited by neutralizing antibodies and poor intratumoral bioavailability. We developed iNV-GOV, a tumor-targeted, low-immunogenic platform that...
ORGANISM(S): Homo sapiens (Human) 
2025-10-03 | PXD067837 | Pride
Inv gov and gov 
GenomicsNur77 induces GSDMC-mediated pyroptosis
Nur77 induces GSDMC-mediated pyroptosis
PRJNA1141494 | ENA
ProteomicsNigericin induced paraptosis-like cell death instead of pyroptosis in corneal keratocytes
Corneal wound healing involves complex cellular processes, including keratocyte cell death, which plays a pivotal role in initiating tissue repair. Recent studies suggest that pyroptosis, characterized by the release of pro-inflammatory factors, occurs during tissue repair which may also contribute ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD058468 | Pride
Proteomics Corneal keratocytes Nigericin 
ProteomicsPyroptosis therapy targeting TNBC
Biomimetic nanococrystals are prepared using the preferred combination of mitoxantrone and gambogic acid for rational drug delivery. The unique mechanism of obtained nanococrystals regulating pyroptosis genes through ribosomal stress is revealed by TMT-proteomics of 4T1 cells.
ORGANISM(S): Mus musculus (Mouse) 
2024-07-27 | PXD053939 | Pride
Mice，4t1 cells，lc-ms/ms 
ProteomicsThe analysis of GSDME-NT binding proteins in the presence or absence of methionine
Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. Thus，the binding proteins of GSDME-NT are detected in the presence or absence of Methionine for futher exploration。
ORGANISM(S): Homo Sapiens 
2025-01-19 | PXD059954 |
GenomicsRuxolitinib reduces macrophage pyroptosis in aplastic anaemia
Ruxolitinib reduces macrophage pyroptosis in aplastic anaemia
PRJNA1235629 | ENA
ProteomicsA CTL-inspired Killing System Reveals Ultralow-dose Chemotherapy is Sufficient for Inducing a Pyroptosis-mediated Antitumour Immune Function
A Cytotoxic T lymphocyte-inspired system capable of using ultralow-dose chemical drugs to manipulate cell death is needed to investigate the antitumour immunotherapy. Recent studies revealed pyroptosis, a proinflammatory type of cell death, could promote antitumour immune function. However, high-dos...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-23 | PXD047873 | Pride
Mouse Antitumor immune Pyroptosis 
GenomicsVesicular transplantation of gasdermin pores propagates pyroptosis
Vesicular transplantation of gasdermin pores propagates pyroptosis
PRJNA1161397 | ENA
MetabolomicsGSDME-controlled pyroptosis promotes muscle repair by coordinating tissue resident macrophages and fibro-adipogenic progenitors
GSDME (Gasdermin E) is a critical protein known for its role in pyroptosis, a form of programmed cell death associated with inflammation. We demonstrated that GSDME as a crucial mediator in muscle repair, particularly in the context of muscle damage induced by cardiotoxin (CTX). Specifically, we fou...
2026-01-05 | MTBLS10509 | MetaboLights
ProteomicsThe analysis of spermidine-binding proteins
Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. This process is regulated by methionine metabolite spermidine，which can bind with proteins to regulate their biological function. Thus，the binding proteins of sp...
ORGANISM(S): Homo Sapiens 
2025-01-21 | PXD060003 |
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