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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
ProteomicsNoncanonical amino acid-aided synthesis of anti-PD-L1 bispecific nanobody for colon cancer immunotherapy
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality, and the incidence of early-onset colon cancer has been increasing globally in recent years. The development of immunotherapies for colon cancer is critical for providing new treatment strategies to combat drug resistanc...
ORGANISM(S): Escherichia coli 
2026-01-12 | PXD069482 | Pride
Bispecific antibody Maldi-tof Noncanonical amino acid 
ProteomicsMachine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids
The pyrrolysyl-tRNA synthetase (PylRS) is widely used to incorporate noncanonical amino acids (ncAAs) into proteins. However, most of ncAA-containing protein yields remain low due to the limited activity of PylRS variants. Here, we apply machine learning (ML) to engineer the tRNA-binding domain of P...
ORGANISM(S): Escherichia coli 
2025-07-25 | PXD065336 | Pride
Lc-ms Sfgfp Noncanonical amino acids 
ProteomicsIntegrating Protein Language Models and Automatic Biofoundry for Enhanced Protein Evolution
Traditional protein engineering methods, such as directed evolution, while effective, are often slow and labor-intensive. Advances in machine learning and automated biofoundry present new opportunities for optimizing these processes. This study devises a protein language model-enabled automatic evol...
ORGANISM(S): Escherichia coli 
2024-12-25 | PXD058768 | Pride
Protein language models Protein engineering Directed evolution Automatic biofoundry 
MetabolomicsSerum and Fecal Metabolomics Analysis in Laboratory-Kenneled Poodles

This study was conducted to investigate the effects of Lycium barbarum polysaccharides and glycopeptide on the serum and metabolomics of laboratory-kenneled Poodles.

2026-03-12 | MTBLS14033 | MetaboLights
MetabolomicsTo elucidate the effects of leaf spot disease on the metabolism of adjacent leaves following its onset
To elucidate the effects of leaf spot disease on the metabolism of adjacent leaves following its onset.
2026-10-22 | MTBLS16045 | MetaboLights
TranscriptomicsNext generation sequencing for patients with hypomyelinating leukodystrophies
Targeted enrichment-based next-generation sequencing or whole exome sequencing were taken for patients with hypomyelinating leukodystrophies to reveal genetic aetiologies. All genomic DNA used in the experiments was extracted from the peripheral leukocytes. A complete kit was synthetized using the A...
ORGANISM(S): Homo sapiens 
2018-02-01 | E-MTAB-6054 | biostudies-arrayexpress
UnknownIncreased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database.
Not available
S-EPMC8341327 | biostudies-literature
UnknownPersonalized medicine modality based on patient-derived xenografts from a malignant transformed GCTB harboring H3F3A G34W mutation.
Not available
S-EPMC8173097 | biostudies-literature
ProteomicsMouse Neuroblastoma Cells Proteome by LC-MS/MS
N2a cells were transfected with pCAGGS vector or pCAGGS-RABV-M (expressing rabies virus matrix protein) for 36 hours, cells were lysed for SDS-PAGE. The area where the proteins were located in the SDS-PAGE was scooped and cut into small pieces of about 1 mm3; the decolorization solution (15 mM K3Fe(...
ORGANISM(S): Mus Musculus 
PXD044493 |
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