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ProteomicsDecoding protein glycosylation by an integrative mass spectrometry-based de novo sequencing strategy
Glycoprotein is one of the most complex biomacromolecule，accounting for over 50% of total human proteins and the majority of biopharmaceuticals, exerting profound influences on various essential biological processes. With multiple N-glycosylation sites and O- glycosylation sites on the protein backb...
ORGANISM(S): Homo Sapiens Bos Taurus 
2024-08-24 | PXD055221 |
UnknownIntegrating Genomic, eQTL, and Mendelian Randomization Analyses to Identify Microglial Drug Targets in Multiple Sclerosis.
Not available
S-EPMC12618184 | biostudies-literature
ProteomicsIntegrated physiological, proteomic and metabolomic analyses of pecan cultivar ‘Pawnee’ adaptation to salt stress
this study analyzed photosynthetic and fluorescence parameters of pecan under hydroponic conditions to simulate salt stress. The results showed that as the duration of salt stress increased, there was a corresponding increase in the intercellular carbon dioxide concentration (Ci) of the leaves, and ...
ORGANISM(S): Carya Illinoinensis 
2021-11-29 | PXD030031 |
ProteomicsEndoglycosidases- treated N-glycosylation site identification
Glycoproteins, representing over 50% of human proteins and most biopharmaceuticals, are crucial for regulating various biological processes. The complexity of multiple glycosylation sites often leads to incomplete sequence coverage and ambiguous glycan modification profiles. Here, we developed an in...
ORGANISM(S): Homo Sapiens 
2024-12-30 | PXD059329 |
UnknownT-Cell Therapy Using Interleukin-21-Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression.
Not available
S-EPMC5477923 | biostudies-literature
ProteomicsRetinal conditional knockout EMC3 in mice
Control and EMC3 CKO retinas (n = 3 each group) at E17.5 and P7 were used for tandem mass spectrometry (LC-MS/MS)–based label-free proteomics
ORGANISM(S): Mus Musculus 
2021-01-04 | PXD023349 |
TranscriptomicsSUDHL-4 cells: suspension vs. co-cultured with HK cells
We first performed miRNA analysis on SU-4 cells in suspension, and after 24 and 48 h of HK co-culture. To ensure that no HK cell contamination occurred, SU-4 cells in suspension and after co-culture were purified by CD19-positive magnetic selection, followed by total RNA isolation. Two-condition exp...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-49253 | biostudies-arrayexpress
TranscriptomicsGlobal Regulation of Alternative Internal Exon Usage by mRNA 3' End Formation Factors [iCLIP-Seq]
iCLIP was performed in duplicates using RBFOX2 and CPSF2 antibodies. iCLIP was performed in duplicates using RBFOX2 and CPSF2 antibodies.
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-60385 | biostudies-arrayexpress
TranscriptomicsGlobal Regulation of Alternative Internal Exon Usage by mRNA 3' End Formation Factors [RNA-Seq]
RNA-seq analysis of samples from Non-silencing, RBFOX2 and CPSF2 knockdown cells We analyzed 6 samples using the Illumina HiSeq 2000. Sequence data was processed by DexSeq. Two biological replicates were performed for Non-silencing, RBFOX2 and CPSF2 knockdown cells
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-60391 | biostudies-arrayexpress
TranscriptomicsmiR-146a promotes the initiation and progression of melanoma by activating Notch signaling
Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. Here we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of m...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-39983 | biostudies-arrayexpress
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