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MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
ProteomicsAn unconventional integrin b3 and CD103 heterodimer improves the anti-tumor immunity of tissue-resident T cells
Current cancer immunotherapies promote recovery of CD103+ tissue-resident memory T cells (Trm) population of the tumor-infiltrating T lymphocytes (TILs). However, not all treated patients exhibit improved anti-tumor immunity and survival, likely due to the immunophenotypical diversity among the C...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD031794 | Pride
Xcr1 Granulysin Itgb3 Tissue-resident Cancer immunotherapy Amino acids Cancer-specific t cells 
UnknownTao-1 is a negative regulator of microtubule plus-end growth.
Not available
S-EPMC2915876 | biostudies-literature
UnknownDrosophila gene tao-1 encodes proteins with and without a Ste20 kinase domain that affect cytoskeletal architecture and cell migration differently.
Not available
S-EPMC4313371 | biostudies-literature
MetabolomicsData processing, multi-omic pathway mapping, and metabolite activity analysis using XCMS Online

Systems biology is the study of complex living organisms, and as such, analysis on a systems-wide scale involves the collection of information-dense data sets that are representative of an entire phenotype. To uncover dynamic biological mechanisms, bioinformatics tools have become essential to fa...

2017-11-23 | MTBLS572 | MetaboLights
ProteomicsThe phosphoproteomic responses of duck (Cairna moschata) to classical/novel duck reovirus infections in the spleen tissue
Duck reovirus (DRV) is a fatal member of the genus Orthoreovirus in the family Reoviridae. The disease caused by DRV leads to huge economic losses to the duck industry. Post-translational modification is an efficient strategy to enhance the immune responses to virus infection. However, the roles of ...
ORGANISM(S): Cairina moschata 
2021-09-09 | PXD016423 | Pride
Duck reovirus  immune response  pattern-recognition receptors  phosphorylation  post-translational modification 
TranscriptomicsGenome-wide analysis of CD8 cells laser captured from skin biopsies during the mucocutaneous HSV-2 reactivation
Analysis of CD8 cells at the gene expression level during the genital HSV-2 reactivation. We would like to get a comprehensive overview on gene expression of CD8 T-cells during the post healing phases of HSV-2 reactivation. The hypothesis is that CD8 T-cells play a immune surveillance function durin...
ORGANISM(S): Homo sapiens 
2012-07-25 | E-GEOD-39625 | biostudies-arrayexpress
UnknownThe phenotypic characteristics of polymorphonuclear neutrophils and their correlation with B cell and CD4+T cell subsets in thyroid-associated ophthalmopathy.
Not available
S-EPMC11371595 | biostudies-literature
ProteomicsComparative proteomic analysis revealed the differential responses to novel duck reovirus infection in the bursa of Fabricius of Cairna moschata
Duck reovirus (DRV) is well-studied aquatic bird virus belonging to the Orthoreovirus genus of the Reoviridae family. The bursa of Fabricius is an immunologically organ against virus invasion. However, the responses of the bursa of Fabricius of Cairna moschata to DRV infection are largely unknown. T...
ORGANISM(S): Cairina moschata 
2022-08-12 | PXD025093 | Pride
Cairna moschata  differential accumulated protein  reovirus  proteomic analysis  the bursa of fabricius 
ProteomicsViral control by a unique cytotoxic SARS-CoV-2 spike protein-specific CD4+ T cell population
Little is known of the role of cytotoxic CD4+ T-cells (CTLs) in the control of human viral replication. Here, we investigate CD4+ T-cell responses to three immunodominant SARS-CoV-2 epitopes identified in our study cohort, and evaluate cytotoxic activity and antiviral cytokine production in response...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2025-08-15 | PXD042469 | Pride
Human Epitotpes Sars-cov-2 Cd4+ tcells Lc-ms/ns 
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