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TranscriptomicsHuman XCR1+ Dendritic Cells Derived In Vitro from CD34+ Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells
Functional characterization of human dendritic cell subsets is limited due to the very low frequency of these cells in vivo. We developed an in vitro culture system for the simultaneous generation of XCR1+ DCs and MoDCs from cord blood CD34+ cells. Their global gene expression profiles at steady sta...
ORGANISM(S): Homo sapiens 
2014-07-23 | E-GEOD-57671 | biostudies-arrayexpress
TranscriptomicsThymic XCR1+ dendritic cells undergo a functional maturation fundamentally similar to that of peripheral tolerogenic XCR1+ dendritic cells
Dendritic cells (DC) play critical roles in central and peripheral T cell tolerance. DC found in the steady-state periphery undergo an homeostatic, tolerogenic, maturation that promotes interaction with naive T cells and induction of abortive responses. In contrast, thymic DC are thought to exist so...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-71166 | biostudies-arrayexpress
TranscriptomicsThymic XCR1+ dendritic cells undergo a functional maturation irrespective of type I interferon and of the microflora
Dendritic cells (DC) play critical roles in central and peripheral T cell tolerance. DC found in the steady-state periphery undergo an homeostatic, tolerogenic, maturation that promotes interaction with naive T cells and induction of abortive responses. In contrast, thymic DC are thought to exist so...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-78171 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of splenic XCR1+ dendritic cells from untreated or day 1.5 MCMV-infected mice
The goal of this experiment was to use global gene expression profiling to assess the global genetic reprogramming of spleen XCR1+ DC early after MCMV infection in vivo, using on Affymetrix Mouse Gene 1.0 ST Array. Comparison of the gene expression programs of XCR1+ dendritic cells isolated from the...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-71169 | biostudies-arrayexpress
TranscriptomicsA fraction of steady state splenic XCR1+ dendritic cells undergo an homeostatic maturation as assessed by their upregulation of CCR7 or of IL-12, and by their profound genetic reprogramming
XCR1+ dendritic cells (DC) have been shown to excel in antigen cross-presentation for the activation of naïve CD8 T cells. This property was reported to be associated to the subset of the XCR1+ DC expressing IL-12b upon ex vivo stimulation for 24 h with a mixture of CpG, IFN-γ, and GM-CSF (Lin ML ...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-71167 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse spleen XCR1+ DC at steady state, 3 hours after polyI:C or 12 hours after STAg i.v. injection
The goal of this experiment was to use global gene expression profiling to compare the global genetic reprogramming of spleen XCR1+ DC upon in vivo stimulation with a viral-type ligand, polyI:C which strongly induces type I interferons, versus with a ligand derived from an intracellular parasite whi...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-71168 | biostudies-arrayexpress
UnknownCrucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis.
Not available
S-EPMC4804307 | biostudies-literature
UnknownMolecular basis for chemokine recognition and activation of XCR1.
Not available
S-EPMC11621518 | biostudies-literature
TranscriptomicsThymic XCR1+ dendritic cells undergo a functional maturation fundamentally similar to that of peripheral tolerogenic XCR1+ dendritic cells
Dendritic cells (DC) play critical roles in central and peripheral T cell tolerance. DC found in the steady-state periphery undergo an homeostatic, tolerogenic, maturation that promotes interaction with naive T cells and induction of abortive responses. In contrast, thymic DC are thought to exist so...
ORGANISM(S): Mus musculus 
2016-08-22 | GSE71166 | GEO
UnknownDevelopment and function of chicken XCR1+ conventional dendritic cells.
Not available
S-EPMC10634274 | biostudies-literature
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