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ProteomicsSerum proteomics and metabolomics reveal the characteristics of the A1762T/G1764A mutations in conjunction with the G1896A mutation.
Background and Objective: CHB is a complex heterogeneous disease with a high incidence and mortality rate. Especially, the mutant strains with A1762T/G1764A and G1896A mutations gradually gained survival advantages during the population evolution process. However, our current understanding of the po...
ORGANISM(S): Homo sapiens (Human) 
2026-04-14 | PXD066939 | Pride
Proteomics Gene mutation Non-targeted metabolomics Genomics analysis Chb 
ProteomicsIntegrated Single-Cell Proteomics Analysis on an Active Matrix Digital Microfluidic Chip
We introduce and implement a comprehensive single-cell proteomics sample pre-treatment solution based on an active matrix digital microfluidics chip(AM-DMF-SCP). This platform accommodates high-throughput single-cell isolation and seamless, non-destructive sample pre-treatment, characterized by its ...
ORGANISM(S): Homo Sapiens 
2024-04-15 | PXD048434 |
UnknownCrop coefficient determination and evapotranspiration estimation of watermelon under water deficit in a cold and arid environment.
Not available
S-EPMC10312094 | biostudies-literature
UnknownAmoebal endosymbiont Parachlamydia acanthamoebae Bn9 can grow in immortal human epithelial HEp-2 cells at low temperature; an in vitro model system to study chlamydial evolution.
Not available
S-EPMC4314085 | biostudies-literature
UnknownHSP90AA1 is an unfavorable prognostic factor for hepatocellular carcinoma and contributes to tumorigenesis and chemotherapy resistance.
Not available
S-EPMC11736399 | biostudies-literature
UnknownL007-0069 kills Staphylococcus aureus in high resistant phenotypes.
Not available
S-EPMC11803045 | biostudies-literature
UnknownEpidemiological trends and mid-term to long-term outcomes of acetabular fractures in the elderly in China.
Not available
S-EPMC10799810 | biostudies-literature
MetabolomicsPatA mediates biofilm formation and drugs resistance through regulating the synthesis of glycolipids and lipids in mycobacterium PatA mediates a novel mycolic acid synthesis pathway and regulates biofilm formation in mycobacterium
Glycolipids and lipids are prominent components of bacterial cell wall that play critical roles not only in maintaining the biofilm formation but also in resistance to environmental stress. PatA is an essential membrane associated acyltransferase involved in the biosynthesis of phosphatidyl-myo-inos...
2023-05-22 | MTBLS6758 | MetaboLights
ProteomicsFam170a deficiency causes male infertility by impairing histone-to-protamine exchange during mouse spermiogenesis
Families with sequence similarity 170 members A (Fam170a) deficiency caused abnormal sperm nuclear morphology and male infertility in mice, mirroring the observation of very low Fam170a transcription in sperm of infertile men with teratozoospermia.Fam170a directly interacted with the deubiquitinatin...
ORGANISM(S): Mus Musculus 
2024-11-10 | PXD057721 |
ProteomicsChromatin bound O-GlcNAc proteins related to stress response and transcriptional regulation.
O-GlcNAcylation performs a critical role in regulating stress response program and cellular homeostasis. However, systematic studies of O-GlcNAc regulated genotoxic stress-responsive transcriptional reprograming have been limited. The GalNAz metabolic labeled global chromatin-associated proteins wer...
ORGANISM(S): Homo Sapiens 
2020-08-30 | PXD016713 |
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