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UnknownNeutrophil membrane-encapsulated nanosonosensitizer with ultrasound-reinforced ferroptosis in Pseudomonas aeruginosa pneumonia.
Not available
S-EPMC12465798 | biostudies-literature
GenomicsInteraction with WDR5 promotes target gene recognition and tumorigenesis by MYC
We report a comparison of the genome-wide binding patterns of MYC and WDR5, and the effects of a mutation in MYC (WBM) that disrupt the MYC-WDR5 interaction. The experimental design included two distinct experimental strategies. For comparison of genome-wide binding patters of wild-type (WT) and WDR...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-60897 | biostudies-arrayexpress
TranscriptomicsFetal lung development
Fetal lung development is a complex biological process, which involves temporal and spatial regulations of many genes. To understand molecular mechanisms of this process, we investigated gene expression profiling of lungs at gestational day 18, 19, 20, 21, new born, and adult rats using in-house rat...
ORGANISM(S): Rattus norvegicus 
2010-07-01 | E-GEOD-3302 | biostudies-arrayexpress
TranscriptomicsExpression profiling of MCF10A cells in 2D and 3D culture
In these microarray experiments, we characterize the gene expression of mammary epithelial cells (MCF10A cells) grown in either a traditional monolayer cell culture setting (2D) or on Matrigel, which induces single MCF10A cells to form organized acinar structures (3D). Morphogenesis of mammary epith...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26148 | biostudies-arrayexpress
TranscriptomicsExpression data from murine colon tissue after exposure to 4% DSS for 6 days DSS followed by 4 days of water or 1% L-arginine
L-Arginine (L-Arg) is the substrate for both inducible nitric oxide synthase and arginase, which are upregulated in human IBD and in mouse colitis models. We have found that L-Arg supplementation enhances wound restitution in vitro, and improves the clinical parameters of weight loss, survival, and ...
ORGANISM(S): Mus musculus 
2012-06-26 | E-GEOD-34874 | biostudies-arrayexpress
TranscriptomicsArsenic-induced Changes in L2 Cells
Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the molecular mechanisms by which arsenic causes cancer are still unclear. We hypothesized that ...
ORGANISM(S): Rattus norvegicus 
2011-12-23 | E-GEOD-9790 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of Alveolar epithelial cells
Freshly isolated type I and type II alveolar epithelial cells were investigated for transcriptomes with dual-color DNA microarray using 3DNA 50 kit.
ORGANISM(S): Rattus norvegicus 
2010-06-11 | E-GEOD-2160 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in AEC II during hyperoxia exposure and recovery
In this study, type II alveolar epithelial cells (AEC II) were isolated from normal, hyperoxia exposed (day 0) and recovery (day 1,3,5 and 7) rats with high purity (~95%). Total RNA from isolated cells were used for dual color DNA microarray hybridization with 3DNA 50 kit version 2. Keywords: time-c...
ORGANISM(S): Rattus norvegicus 
2010-06-11 | E-GEOD-2707 | biostudies-arrayexpress
TranscriptomicsmRNA expression data from mice infected with H. pylori treated with estradiol, tamoxifen, or placebo
We are investigating the mRNA expression profiles of gastric tissue within H. pylori-infected mice treated with estradiol, tamoxifen, or placebo We used microarrays to compare the global mRNA expression profiles in H. pylori infected mice in response to estradiol and tamoxifen Male mice were infecte...
ORGANISM(S): Mus musculus 
2011-06-30 | E-GEOD-29715 | biostudies-arrayexpress
TranscriptomicsHistone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat
In Saccharomyces cerevisiae, ubiquitylation of histone H2B signals methylation of histone H3 at lysine residues 4 (K4) and 79. These modifications occur at active genes but are believed to stabilize silent chromatin by limiting movement of silencing proteins away from heterochromatin domains. In the...
ORGANISM(S): Saccharomyces cerevisiae 
2011-12-02 | E-GEOD-27934 | biostudies-arrayexpress
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