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MetabolomicsThe functional role of OGDH for maintaining mitochondrial respiration and identity of primed human embryonic stem cells

Human embryonic stem cells (hESCs) can self-renew infinitely or differentiate into the 3 germ layer lineages in vitro with certain cues, holding great promise to model early human embryo development ex vivo. It is wildly accepted that hESCs take advantage of both glycolysis and ...

2022-03-03 | MTBLS4223 | MetaboLights
MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
TranscriptomicsTranscriptome dynamics during the transition from anaerobic photosynthesis to aerobic respiration in R. sphaeroides
we performed time series microarray analyses to investigate transcriptome dynamics during the transition from anaerobic photosynthesis to aerobic respiration. Published on J. Bacteriol., 190 (1), 286-299, 2008. Major changes in gene expression profiles occurred in the initial 15 min after the shift ...
ORGANISM(S): Rhodobacter sphaeroides 2.4.1 
2008-07-28 | E-GEOD-12269 | biostudies-arrayexpress
TranscriptomicsThe regulatory role of ferric uptake regulator (Fur) during anaerobic respiration of Shewanella piezotolerans WP3
Purpose: The goal is to study the regulatory role of ferric uptake regulator (Fur) during anaerobic respiration in Shewanella piezotolerans WP3 mRNA profiles of WP3 wild type (WP3) and the fur mutant (Fur) were generated by deep sequencing using Illumina HiSeq 2000.
ORGANISM(S): Shewanella piezotolerans WP3 
2016-06-10 | E-GEOD-47773 | biostudies-arrayexpress
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
TranscriptomicsExpression data from Shewanella oneidensis MR-1 wild-type, Δcrp, and ΔcyaC strains
Anaerobic respiration in the metal reducer Shewanella oneidensis MR-1, unlike other bacteria, is regulated by the cAMP receptor protein, CRP. Three putative genes, cyaA, cyaB, and cyaC, predicted to encode class I, class IV, and class III adenylate cyclases respectively, have been identified in the ...
ORGANISM(S): Shewanella oneidensis MR-1 
2010-06-19 | E-GEOD-15657 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of Desulfovibro vulgaris Hildenborough following transitions between sulfate respiration and syntrophy
Managing tradeoffs through gene regulation is believed to be critical for the success of a generalist in a fluctuating resource environment. To investigate this hypothesis in depth, we imposed a fluctuating environment that required a representative community of the sulfate-reducing generalist Desul...
ORGANISM(S): Desulfovibrio vulgaris str. Hildenborough 
2015-09-17 | E-GEOD-73105 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes in Escherichia coli during a shift from fermentation to Trimethylamine-N-oxide (TMAO) respiration
Gene-expression measurements were made over a 24 h time course as fermentative steady state E. coli cells were subjected to a shift to TMAO respiration.
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-12-13 | E-MTAB-2784 | biostudies-arrayexpress
TranscriptomicsExpression data of Actinobacillus pleuropneumoniae 4074 under aerobic and anaerobic environment
Actinobacillus pleuropneumoniae is an important porcine respiratory pathogen causing great economic losses in the pig industry worldwide. Oxygen deprivation is a stress that A. pleuropneumoniae will encounter during both early infection and the later, persistent stage. To understand modulation of A....
ORGANISM(S): Actinobacillus pleuropneumoniae serovar 1 str. 4074 
2014-06-30 | E-GEOD-39801 | biostudies-arrayexpress
TranscriptomicsAdaption of Dinoroseobacter shibae to anaerobic conditions
To unravel the adaptation strategies of D. shibae to anaerobic conditions in microaerobic to anaerobic parts of the ocean and to define the underlying regulatory network an anaerobic shift experiment in Salt-Water-Medium in a chemostate was established. Transcriptome analyses were used to investigat...
ORGANISM(S): Dinoroseobacter shibae 
2013-08-30 | E-GEOD-47445 | biostudies-arrayexpress
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