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ProteomicsIdentification of cellular CDK9 substrates using an analog-sensitive cell line
Analog-sensitive kinase technology allows for specific inhibition of a given kinase. Here we utilize an analog-sensitive CDK9 cell line to determine the impact of CDK9 inhibition on the phospho-proteome of human cells. Specifically, we aim to identify substrates of CDK9 in a quantitative way using s...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD014825 | Pride
Analog-sensitive Mass spectrometry P-tefb Protein phosphorylation 
GenomicsRNA-Seq for validating the RNA expression of wild type and analog sensitive CDK12 and CDK13 in analog sensitive MV4 11 cell lines that generated by CRISPR HDR
RNA-Seq for validating the RNA expression of wild type and analog sensitive CDK12 and CDK13 in analog sensitive MV4 11 cell lines that generated by CRISPR HDR
PRJNA593228 | ENA
TranscriptomicsRNA-Seq for validating the RNA expression of wild type and analog sensitive CDK12 and CDK13 in analog sensitive MV4;11 cell lines that generated by CRISPR HDR
We used Poly-A enriched RNA-Seq to validate CDK12, CDK13 anlalog senstive mutationsand their expression level in the cell lines that has analog sensitive mutations that were introduced by CRISPR HDR
ORGANISM(S): Homo sapiens 
2020-04-29 | GSE141366 | GEO
GenomicsNAD+ Analog-sensitive PARPs Reveal a Role for PARP-1 in Transcription Elongation
NAD+ Analog-sensitive PARPs Reveal a Role for PARP-1 in Transcription Elongation
PRJNA299154 | ENA
GenomicsPol II and CTD Phosphorylation of ATP-analog sensitive Kin28 budding yeast
Pol II and CTD Phosphorylation of ATP-analog sensitive Kin28 budding yeast
PRJNA325829 | ENA
ProteomicsIdentification of RSK substrates using an analog-sensitive kinase approach
RSK1 and RSK4 are two of the four members of the p90 ribosomal protein S6 kinases (RSK) family. These kinases are downstream kinases of mitogen-activated protein kinase 1 (ERK or MAPK1) in the ERK MAP kinase pathway. RSKs are implicated in fine tuning of cellular processes such as translation, trans...
ORGANISM(S): Homo sapiens (Human) 
2024-02-06 | PXD047020 | Pride
Rsk1 Rsk4 Mapk pathway Kinase Substrate 
TranscriptomicsD9, a novel 3-Deazaneplanocin A (DZNep) analog, is efficacious in targeting acute myeloid leukemia (AML) (Sensitive vs Resistance)
We and others have previously reported that 3-Deazaneplanocin A (DZNep) is a histone methylation inhibitor that has a wide range anticancer effects in a variety of human cancers. Here, using acute myeloid leukemia as a model, we reported a less toxic analog of DZNep, named D9, that is shown to be ef...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-59624 | biostudies-arrayexpress
GenomicsPol II and CTD Phosphorylation ChIP-chip of ATP-analog sensitive Kin28 budding yeast
Pol II and CTD Phosphorylation ChIP-chip of ATP-analog sensitive Kin28 budding yeast
PRJNA325831 | ENA
UnknownAnalog sensitive chemical inhibition of the DEAD-box protein DDX3.
Not available
S-EPMC4815421 | biostudies-literature
UnknownIdentification of RSK substrates using an analog-sensitive kinase approach.
Not available
S-EPMC10945272 | biostudies-literature
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