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MetabolomicsHFD(high-fat diet) Mouse Cecal Content Metabolome

Cecal content metabolome was performed on high-fat diet (HFD)-induced obese mice to investigate the impact of Christensenella intestinihominis MNO-863 on the gut metabolome. The obese&nbs...

2025-09-30 | MTBLS13079 | MetaboLights
MetabolomicsA low protein diet drives short and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy

Despite the largely beneficial impact of bariatric surgery on obesity and metabolic disease, many patients continue to suffer from obesity after surgery and weight recurrence is common. The success of bariatric surgery may be impacted by diet. While bariatric surgery guidelines recommend a high-p...

2025-10-13 | MTBLS13046 | MetaboLights
MetabolomicsInvestigating diet to control asparagine uptake as an adjunct to asparaginase treatment

Refinements of multidrug regimens, and particularly the addition of L-asparaginase, resulted in an immediate gain in survival for pediatric acute lymphoblastic leukemia patients. Yet L-asparaginase has substantial side effects which may require dose reductions or delays in subsequent doses. There...

2026-01-25 | MTBLS13764 | MetaboLights
MetabolomicsInfluence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome
Although the gut microbiome plays important roles in host physiology, health and disease, we lack understanding of the complex interplay between host genetics and early life environment on the microbial and metabolic composition of the gut. We used the genetically diverse Collaborative Cross mouse s...
2016-10-05 | MTBLS345 | MetaboLights
MetabolomicsChronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.
Inorganic nitrate (NO3-) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the Metabolic Syndrome (MetS), type-II diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). Administration of NO3- to endothelial nitric o...
2025-07-14 | MTBLS9526 | MetaboLights
MetabolomicsSynergistic Effects of High-Fiber Diet and N-Carbamylglutamate on Sow Reproductive Performance via Uterine Microbiota-PI3K/Akt Modulation

Uterine microbiome is crucial for embryo implantation and pregnancy by creating a favorable environment. While both high fiber diet and N-Carbamylglutamate (NCG) have been individually demonstrated to enhance reproductive efficiency in sows, their potential synergistic effects and the involvement...

2026-01-08 | MTBLS13635 | MetaboLights
MetabolomicsSynergistic Effects of High-Fiber Diet and N-Carbamylglutamate on Sow Reproductive Performance via Uterine Microbiota-PI3K/Akt Modulation

Uterine microbiome is crucial for embryo implantation and pregnancy by creating a favorable environment. While both high fiber diet and N-Carbamylglutamate (NCG) have been individually demonstrated to enhance reproductive efficiency in sows, their potential synergistic effects and the involvemen...

2026-01-07 | MTBLS13627 | MetaboLights
ProteomicsPhosphoproteomic analysis reveals enhanced PKA signaling in aged skeletal muscle is suppressed by caloric restriction
Although caloric restriction (CR) was first shown to extend the lifespan of rodents over 75 years ago, the underlying mechanisms remain unclear. Additionally, the majority of published studies have focused on the effects of short-term CR. To better understand cell signaling alterations in a tissue k...
ORGANISM(S): Mus Musculus (mouse) 
2021-01-30 | PXD018455 | JPOST Repository
MetabolomicsMulti-omics Elucidates Gut Microbiota-Driven Mechanisms of Lipid Deposition in Pigs Fed a DDGS Diet

Abstract:

Background: Corn dried distillers’ grains with solubles (DDGS) is a cost-effective alternative feed ingredient in swine diets. However, its negative impact on carcass fat quality, characterized by increased polyunsaturated fatty acids (PUFAs) and reduced fat firmness, fundamentall...

2026-03-16 | MTBLS14058 | MetaboLights
ProteomicsUse of Proteomics for Dietary Reconstruction: a Case Study using Animal Teeth from Ancient Mesopotamia
This research examines animal teeth from Early Dynastic (2900-2350 BC) Mesopotamia (Southern Iraq) to assess animal management practices and identify consumption patterns in animal diets. The objective to answer larger questions about food management and environmental resilience in ancient early com...
ORGANISM(S): environmental samples <mammals> 
2025-03-24 | PXD050140 | Pride
Ancient mesopotamia Dietary reconstruction Osteological animal Animal teeth proteomics 
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