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MetabolomicsOVCAR-3 spheroid-derived cells display distinct metabolic profiles
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid derived cells displayed numerous hallmarks of cancer stem cells, which are chemo and radioresistant cells thought to be a significant cau...
2015-01-08 | MTBLS152 | MetaboLights
ProteomicsPHF20 and PHF20L1 in NSL complex
The methyl lysine readers PHF (plant homeodomain finger) 20 (PHF20) and its homolog PHF20 Like 1 (PHF20L1) are known components of the NSL (non-specific lethal) complex that regulates gene expression through its histone acetyltransferase activity. In the current model, both PHF homologs coexist in t...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD029258 | Pride
Ap-ms Phf20 Phf20l1 U2os 
MetabolomicsB cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size.

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
GenomicsIdentification of a novel Aire-regulating cis-regulatory element using H3K27ac ChIP-seq
Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the expression of a diverse set of tissue-specific antigens (TSAs), which are presented and help tol...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-74257 | biostudies-arrayexpress
MetabolomicsBiodiversity in marine invertebrate responses to acute warming revealed by a comparative multi-omics approach
Understanding species' responses to environmental change underpins our abilities to make predictions on future biodiversity under any range of scenarios. In spite of the huge biodiversity in most ecosystems, a model species approach is often taken in environmental studies. To date, we still do not k...
2016-06-23 | MTBLS336 | MetaboLights
UnknownRheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice.
Not available
S-EPMC4028066 | biostudies-literature
UnknownPhase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Not available
S-EPMC4348638 | biostudies-literature
UnknownRapid-rate nonsustained ventricular tachycardia found on implantable cardioverter-defibrillator interrogation: relationship to outcomes in the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial).
Not available
S-EPMC3760407 | biostudies-literature
UnknownIncorporating Digital Tools to Improve Clinical Trial Infrastructure: A White Paper From the Digital Engagement Committee of SWOG.
Not available
S-EPMC6668704 | biostudies-literature
MetabolomicsDistinct metabolic responses of an ovarian cancer stem cell line

Background

Cancer metabolism is emerging as an important focus area in cancer research. However, the in vitro cell culture conditions under which much cellular metabolism research is performed differ drastically from in vivo tumor conditions, which are characterized by variations in the leve...
2021-11-05 | MTBLS150 | MetaboLights
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