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GenomicsChIP-seq analysis of PHF20 and Wdr5 binding sites in ESCs
Although reprogramming of somatic cells to generate inducible pluripotent stem cells (iPSCs) is associated with remarkable epigenetic changes, the role and mechanisms of epigenetic factors in this process remains poorly understood. Here we describe identification of Jmjd3 as a potent negative regula...
ORGANISM(S): Mus musculus 
2013-12-06 | E-GEOD-43247 | biostudies-arrayexpress
ProteomicsPHF20 and PHF20L1 in NSL complex
The methyl lysine readers PHF (plant homeodomain finger) 20 (PHF20) and its homolog PHF20 Like 1 (PHF20L1) are known components of the NSL (non-specific lethal) complex that regulates gene expression through its histone acetyltransferase activity. In the current model, both PHF homologs coexist in t...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD029258 | Pride
Ap-ms Phf20 Phf20l1 U2os 
GenomicsLoss of PHF20 does not negatively affect deposition of H4K16 acetylation, but does impact the expression of MOF targets
Protein post-translational modifications transmit signals in part by creating binding sites for effector molecules. This is especially true in epigenetic pathways where histone tails are heavily modified, resulting in the recruitment of molecules that can affect transcription. One such molecule, pla...
ORGANISM(S): Mus musculus 
2012-02-27 | E-GEOD-29306 | biostudies-arrayexpress
GenomicsMethyl-lysine readers PHF20 and PHF20L1 define two distinct NSL complexes
Methyl-lysine readers PHF20 and PHF20L1 define two distinct NSL complexes
PRJNA779539 | ENA
GenomicsHomozygous deletion of the epigenetic regulator PHF20 in individuals with neurodevelopmental disorder
Homozygous deletion of the epigenetic regulator PHF20 in individuals with neurodevelopmental disorder
PRJNA1363932 | ENA
TranscriptomicsIdentification of genes and pathways that regulated by PHF20 via gene expression profile analysis in U87 cell with PHF20 silencing
Glioblastoma (GBM) is the most common tumor of the central nervous system with poor prognosis. PHF20 was highly expressed in primary human glioma specimens. However, the molecular mechanism of by which PHF20 regulated glioblastoma remains poorly understood. In the study, we investigate the gene expr...
ORGANISM(S): Homo sapiens 
2017-10-31 | GSE93680 | GEO
GenomicsMethyl-lysine readers PHF20 and PHF20L1 define two distinct NSL complexes
The methyl lysine readers PHF (plant homeodomain finger) 20 (PHF20) and its homolog PHF20 Like 1 (PHF20L1) are known components of the NSL (non-specific lethal) complex that regulates gene expression through its histone acetyltransferase activity. In the current model, both PHF homologs coexist in t...
ORGANISM(S): Homo sapiens 
2022-03-02 | GSE188601 | GEO
TranscriptomicsPHF20 readers link methylation of histone H3K4 and p53 with H4K16 acetylation
PHF20 is a core component of the lysine acetyltransferase complex MOF-NSL that produces the major epigenetic mark, H4K16ac, and is necessary for transcriptional regulation and DNA repair, however the role of PHF20 in the complex remains elusive. Here, we report on functional crosstalk between epigen...
ORGANISM(S): Homo sapiens 
2017-05-22 | GSE82115 | GEO
UnknownIdentification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53.
Not available
S-EPMC3322870 | biostudies-literature
UnknownPHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Not available
S-EPMC5125728 | biostudies-literature
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