Sort   by:  
 Page size 
ProteomicsNardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of apoptotic pathways. Here, we find that development of anoikis resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, ex...
ORGANISM(S): Homo sapiens (Human) 
2023-12-23 | PXD042993 | Pride
Plk3 Nardilysin (nrdc) metalloendopeptidase cleavage C-fos Anoikis Pancreatic ductal adenocarcinoma (pdac) Post-translational mechanism (ptm) Genetically engineered mouse models (gemms) Plk1 Kinase activation Metastasis 
ProteomicsA metabolism-epigenome axis controls early events in CD4+ T cell activation
Upon antigen-specific T Cell Receptor (TCR) engagement, human CD4+ T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming utilizing aerobic glycolysis together with maintenance of oxidative phosphorylation1,2. However, the role of g...
ORGANISM(S): Homo sapiens (Human) 
2023-10-27 | PXD018132 | Pride
Human cd4+ t cells Antigen-specific t cell receptor (tcr) engagement 
TranscriptomicsGene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice
Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kB activation and completely suppressed PDAC development. Our findings demonstrated that NF-kB is...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-33322 | biostudies-arrayexpress
TranscriptomicsKras-induced ikk2/nf-kappaB activation by IL-1 alpha and p62 freedforward loops is required for development of pancreatic ductal adenocarcinoma
This SuperSeries is composed of the following subset Series: GSE27478: Gene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice GSE33322: Gene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-c...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-33323 | biostudies-arrayexpress
UnknownCost-Effectiveness of a Community-Based Diabetes Prevention Program with Participation Incentives for Medicaid Beneficiaries.
Not available
S-EPMC6232439 | biostudies-literature
UnknownCombined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study.
Not available
S-EPMC4678181 | biostudies-literature
UnknownClinicopathologic Significance of Mismatch Repair Defects in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study.
Not available
S-EPMC5012715 | biostudies-literature
UnknownThe effects of financial incentives on diabetes prevention program attendance and weight loss among low-income patients: the We Can Prevent Diabetes cluster-randomized controlled trial.
Not available
S-EPMC7580006 | biostudies-literature
UnknownOccupational medicine clinical practice data reveal increased injury rates among Hispanic workers.
Not available
S-EPMC6590790 | biostudies-literature
UnknownUsing advanced racial and ethnic identity demographics to improve surveillance of work-related conditions in an occupational clinic setting.
Not available
S-EPMC9314926 | biostudies-literature
Sort   by:  
 Page size