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GenomicsCUT&RUN Targeting c-FOS, c-JUN and SOX2 in neurospheres derived from mouse brain cells
Other than in the development of the brain, SOX2 is essential for the long-term self-renewal of neural stem cells (NSCs). The mechanisms of how SOX2 maintains the stemness of NSCs is not yet understood. We have identified Fos as a downstream target of SOX2, and therefore used CUT&RUN to investigate ...
ORGANISM(S): Mus musculus 
2021-04-01 | E-MTAB-9897 | biostudies-arrayexpress
TranscriptomicsInterplay between AP-1 and ERalpha in regulating gene expression and proliferation networks in breast cancer cells
Estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERalpha can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interaction...
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-36586 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse osteoclastogenic splenocytes
Effect of c-fos expression in osteoclastogenic splenocytes.
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-676 | biostudies-arrayexpress
TranscriptomicsExpression analyses of inducible c-Fos expressing kerationcytes
Expression analyses comparing c-Fos expressing keratinocytes vs non-expressing controls. Skin squamous cell carcinomas (SCCs) are the second most prevalent skin cancers. Chronic skin inflammation has been associated with the development of SCCs, but the contribution of skin inflammation to SCC devel...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-50621 | biostudies-arrayexpress
TranscriptomicsEndothelin-1 driven proliferation of PASMC is c-fos dependent
Background: Pulmonary hypertension is a rare disease characterized by pulmonary artery smooth muscle cell (PASMC) proliferation leading to vascularremodeling. Multiple factors have been associated with the vessel wall thickening. However, the responsible mechanisms are not fully understood. Aim: In ...
ORGANISM(S): Mus musculus 
2014-04-11 | E-GEOD-56698 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Fos binding site (K562)
Proto-oncogene c-Fos is a leucine-zipper containing transcription factor which has a DNA binding domain and a transactivation domain. Fos dimerizes with another transcription factor Jun to form AP1 transcription factor. The AP-1 complex has been implicated in transformation and progression of cancer...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-19546 | biostudies-arrayexpress
TranscriptomicsThe AP-1 Transcription Factor c-Jun Prevents Stress-Imposed Maladaptive Remodeling of the Heart
Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response) through expansion of sarcomeres with the aim to increase contractility. However, conditions of increased workload can induce both adaptive and ma...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-47898 | biostudies-arrayexpress
ProteomicsNardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of apoptotic pathways. Here, we find that development of anoikis resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, ex...
ORGANISM(S): Homo sapiens (Human) 
2023-12-23 | PXD042993 | Pride
Plk3 Nardilysin (nrdc) metalloendopeptidase cleavage C-fos Anoikis Pancreatic ductal adenocarcinoma (pdac) Post-translational mechanism (ptm) Genetically engineered mouse models (gemms) Plk1 Kinase activation Metastasis 
Transcriptomicsthe influence of a modification of the gut microbiota composition on the hepatic steatosis induced by n-3 polyunsaturated fatty acid (PUFA) depletion
in the present study, we evaluated whether microbiota modulation is able to restore hepatic steatosis induced by n-3 PUFA depletion in mice. For this purpose, mice were fed during three months with a n-3 PUFA-depleted diet (presenting a high n-6/n-3 PUFA ratio), and then supplemented with fructoolig...
ORGANISM(S): Mus musculus 
2012-12-12 | E-GEOD-31727 | biostudies-arrayexpress
GenomicsCUT&RUN Targeting c-FOS, c-JUN and SOX2 in neurospheres derived from mouse brain cells
CUT&RUN Targeting c-FOS, c-JUN and SOX2 in neurospheres derived from mouse brain cells
PRJEB41862 | ENA
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