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UnknownClearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia.
Not available
S-EPMC6008108 | biostudies-literature
TranscriptomicsRegulation of Gene Expression by Connective Tissue Growth Factor (CTGF) in Mesenchymal Stromal Cells (MSCs)
mRNA from bone marrow-derived MSCs stably expressing CTGF-specific shRNA (or empty vector control) was analyzed for differential gene expression. Significant differences were found in cell proliferation-related genes, especially genes related to the M phase of the cell cycle, which were down-regulat...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-47575 | biostudies-arrayexpress
UnknownThe mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.
Not available
S-EPMC3321858 | biostudies-literature
TranscriptomicsEffects of ONC201 on mantle cell lymphoma cell lines
The small molecule ONC201 is toxic in vitro to multiple cell lines and primary tumor samples of mantle cell lymphoma (MCL) and acute myeloid leukemia, even ones with unfavorable genetic features (notably including TP53 inactivation) or acquired resistance to other agents. Because the mechanism of ac...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-68091 | biostudies-arrayexpress
TranscriptomicsHuman bone and marrow niche formation by mesenchymal progenitors in vivo is predefined by an organotypic epigenetic signature
In this study, we have analyzed DNA methylation characteristics of human mesenchymal stem and progenitor cells (MSPCs) form different tissue sources including bone marrow (BM), white adipose tissue (WAT ), umbilical cord (UC) as well as dermal fibroblasts by using the HumanMethylation450K array. Cel...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-41933 | biostudies-arrayexpress
TranscriptomicsCXCR4/YinYang1/Hsa-let-7a axis functions as tumor suppressor in acute myeloid leukemia
Surface expression of C-X-C chemokine receptor type 4 (CXCR4) in acute myeloid leukemia (AML) has been reported to be an independent prognostic factor for disease relapse and survival. We previously reported that targeting the stromal-derived factor 1M-NM-1 (SDF-1M-NM-1)/CXCR4 axis could overcome re...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-44828 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of patients with acute myeloid leukemia to identify microRNA signatures associated with cytogenetics and prognosis
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
ORGANISM(S): Homo sapiens 
2008-01-10 | E-TABM-405 | biostudies-arrayexpress
TranscriptomicsImplications of the miR-10 family in chemotherapy response of NPM1 mutated AML
Nucleophosmin mutated AML (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Since miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs coul...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-55519 | biostudies-arrayexpress
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