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MetabolomicsSpermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
ProteomicsAndrogen receptor RIME using LNCaP cells
Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) was conducted to examine interactome of androgen receptor (AR) in LNCaP cells.
ORGANISM(S): Homo Sapiens (human) 
2021-09-10 | PXD024030 | JPOST Repository
GenomicsGenome-wide analysis of SUMOylation effects on androgen receptor (AR) binding in HEK293 cells (ChIP-seq)
Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compare...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54109 | biostudies-arrayexpress
GenomicsGenome-wide analysis of SUMOylation effects on androgen receptor (AR) binding in PC-3 cells (ChIP-seq)
Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compare...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54110 | biostudies-arrayexpress
TranscriptomicsGATA2 facilitates steroid receptor coactivator (SRC) recruitment to the androgen receptor (AR) complex
The androgen receptor (AR) is a key driver of prostate cancer (PC), even in the state of castration-resistant PC (CRPC), and frequently even after treatment with second-line hormonal therapies such as abiraterone and enzalutamide. The persistence of AR activity via both ligand-dependent and ligand-i...
ORGANISM(S): Homo sapiens 
2015-01-21 | E-GEOD-63539 | biostudies-arrayexpress
GenomicsPersistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions
The androgen receptor (AR) is a ligand-inducible transcription factor that mediates androgen action in target tissues. Upon ligand binding, the AR binds to thousands of genomic loci and activates a cell-type specific gene program. Prostate cancer growth and progression depend on androgen-induced AR ...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-40050 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles induced by either androgen depletion or androgen receptor knockdown
Although the vital role of the androgen receptor (AR) has been well demonstrated in primary prostate cancers, its role in the androgen-insensitive prostate cancers still remains unclear. Here, we used a small hairpin RNA approach to directly assess AR activity in prostate cancer cells. Reduction of ...
ORGANISM(S): Homo sapiens 
2007-08-08 | E-GEOD-7585 | biostudies-arrayexpress
GenomicsGlucocorticoid Receptor and Androgen Receptor DNA binding in LREX'
LREX' are a LnCAP/AR subline with natural expresison of the glucocorticoid receptor. We used the model to compare the AR and GR cistromes in prostate tissue. We determined the GR cistrone in the presence of Dex (100nM) treatment and the AR cistrome in the presene of DHT (1nM) treatment.
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51497 | biostudies-arrayexpress
TranscriptomicsA genome-wide and dose-dependent inhibition map of androgen receptor binding by small molecules reveals its regulatory program upon antagonism
The androgen receptor plays a critical role throughout the progression of prostate cancer and is an important drug target for this disease. While chromatin immunoprecipitation coupled with massively parallel sequencing (ChIP-Seq) is becoming an essential tool in studying transcription and chromatin...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-32892 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of androgen receptor (AR) SUMOylation effects on gene expression (PC-3).
Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compare...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54104 | biostudies-arrayexpress
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