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Proteins physiologically exist and function as ‘proteoforms’ that arise from one gene but acquire additional function by further variation such as post-translational modification (PTM). When multiple PTMs coexist on single protein molecules top down proteomics becomes the only feasible method; howev...
ORGANISM(S): Homo sapiens (Human) 
2019-11-22 | PXD013766 | Pride
Methylation profiling of SF188 paediatric high grade glioma cell line isogenic clones carrying CRISR/Cas9 frameshift deletions in ATRX
ORGANISM(S): Homo sapiens 
Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.
ORGANISM(S): Homo sapiens 
Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.
ORGANISM(S): Homo sapiens 
We have used Illumina Infinium HumanMethylation450 BeadChip array profiling to profile paediatric high grade gliomas and diffuse intrinsic pontine gliomas. The 450K methylation array is being used to separate brain tumour samples on the basis of their methylation profiles which represent the cell of...
ORGANISM(S): Homo sapiens 
Tyrosine kinase inhibitors (TKIs) are effective treatments for non-small cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) mutations. However, they do not lead to cures, and, on average, relapse occurs typically occurs afterafter an average of one year of continuous treatment....
Data Access Committee EGAC00001000284
To facilitate collaborative research efforts between multi-investigator teams using DNA microarrays, we identified sources of error and data variability between laboratories and across microarray platforms and methods to accommodate this variability. RNA expression data were generated in seven labo...
ORGANISM(S): Mus musculus 
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