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MetabolomicsPomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs
Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of...
2021-10-06 | MTBLS2309 | MetaboLights
MetabolomicsIntegrated multi-omics analysis of liver metabolic dysregulation in ACE2 knockout mice
This study systematically investigated the impact of ACE2 knockout (ACE2KO) on hepatic metabolic homeostasis and its molecular mechanisms, using integrated transcriptomic, proteomic, and metabolomic profiling. ACE2 deficiency exacerbates hepatic lipid accumulation, as evidenced by elevated total cho...
2025-06-23 | MTBLS12389 | MetaboLights
TranscriptomicsGene induction in mouse C57BL6 kidney cortex by angiotensin converting enzyme inhibition (captopril)
Attempt to identify genes whose expression changed in the kidney cortex with angiotensin converting enzyme inhibition. Eleven week-old male C57BL6 mice were treated with captopril at 10mg/kg/day in drinking water for 7 days. The kidney cortex was surgically excised and total RNA was isolated using T...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-57239 | biostudies-arrayexpress
ProteomicsHuman Angiotensin-Converting Enzyme 2-Specific Benzothiazole Allosteric Inhibitor against Pan-Sarbecoviruses
Emerging SARS-CoV-2 variants of concern (VOCs) have demonstrated exceptional transmissibility and a strong dependence on the cellular receptor human angiotensin-converting enzyme 2 (hACE2). In this study, we present MB-32, a benzothiazole-based small molecule allosteric inhibitor of hACE2, w...
ORGANISM(S): Homo sapiens (Human) Sarbecovirus 
2026-05-01 | PXD075140 | Pride
Human Mb-32 Entry inhibtor Angiotensin-converting enzyme 2 Covid19 Allosteric inhibitor Sarbecovirus Benzothiazole Formaldehyde crosslinking 
ProteomicsSARS-Cov2 coronavirus spike protein-induced apoptosis, inflammatory and oxidative stress responses in THP-1-Like-Macrophages: potential role of angiotensin converting enzyme inhibitor (perindopril)
A purified spike (S) glycoprotein for SARS-COV-2 coronavirus was used to studying its effects on THP-1 macrophages, PBMCs and HUVEC cells. The S protein mediates SARS-CoV-2 entry into cells through binding to angiotensin converting enzyme 2 (ACE2) receptors. We measured viability, intracellular cyto...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2021-11-16 | PXD025516 | Pride
Sars-cov-2 spike protein  monocyte/macrophages  inflammation  angiotensin converting enzyme inhibitor  proteomics 
TranscriptomicsEffect of Angiotensin Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Exposure on Intragraft Gene Expression of Kidney Transplant Patients
Treatment with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) has been shown to have anti-inflammatory effects such as decreased growth factors and cytokines in animal models, this effect however, has not been investigated in kidney transplant recipients. We ...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-83095 | biostudies-arrayexpress
ProteomicsThe Plethora of Angiotensin-Converting Enzyme Substrates in Mouse Plasma
Angiotensin converting enzyme (ACE) is known for converting inactive angiotensin I into the potent vasoconstrictor angiotensin II, playing a critical role in blood pressure regulation. However, there is evidence that the dicarboxypeptidase activity of ACE is also essential for other physiological pr...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010258 | Pride
Peptidomics 
TranscriptomicsTranscription profiling of stroke-prone spontaneously hypertensive (SHRSP) rats treated with either an angiotensin II receptor (AT1R) antagonist or an angiotensin converting enzyme (ACE) inhibitor
Renin-angiotensin system (RAS) inhibition reduces stroke and improves brain capillary integrity in stroke prone spontaneously hypertensive rats (SHRSP). We tested the hypothesis that treatment with an angiotensin II receptor subtype 1 (AT1R) antagonist has different effects, compared to an angiotens...
ORGANISM(S): Rattus norvegicus 
2007-10-31 | E-GEOD-1548 | biostudies-arrayexpress
TranscriptomicsAngiotensin converting enzyme inhibition attenuates insterstitial injury in a murine model of chronic glomerulonephritis
Evolution of glomerulonephritis (GN) to tubulointerstitial disease is a universal antecedent to the development of chronic kidney disease (CKD). There is also evidence that angiotensin converting enzyme (ACE) inhibition may attenuate the development of CKD in some forms of glomerulonephritis. We t...
ORGANISM(S): Mus musculus 
2013-07-30 | E-GEOD-49323 | biostudies-arrayexpress
UnknownAngiotensin-Converting Enzyme-2
Not available
S-EPMC7150073 | biostudies-literature
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