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MetabolomicsIntegrated multi-omics analysis of liver metabolic dysregulation in ACE2 knockout mice
This study systematically investigated the impact of ACE2 knockout (ACE2KO) on hepatic metabolic homeostasis and its molecular mechanisms, using integrated transcriptomic, proteomic, and metabolomic profiling. ACE2 deficiency exacerbates hepatic lipid accumulation, as evidenced by elevated total cho...
2025-06-23 | MTBLS12389 | MetaboLights
MetabolomicsPomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs
Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of...
2021-10-06 | MTBLS2309 | MetaboLights
ProteomicsCirculating ACE2-expressing Extracellular Vesicles as an Innate Antiviral Response and A Decoy Therapy to Block Broad Strains of SARS-CoV-2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)has caused the pandemic of the coronavirus induced disease 2019 (COVID-19) with 216 million cases and 4.5 million deathsas of September 2021.Thathas been exacerbated by mutated variants such as α, β, and with high infection rates and i...
ORGANISM(S): Homo Sapiens (human) 
2021-12-10 | PXD029662 | JPOST Repository
ProteomicsHuman Angiotensin-Converting Enzyme 2-Specific Benzothiazole Allosteric Inhibitor against Pan-Sarbecoviruses
Emerging SARS-CoV-2 variants of concern (VOCs) have demonstrated exceptional transmissibility and a strong dependence on the cellular receptor human angiotensin-converting enzyme 2 (hACE2). In this study, we present MB-32, a benzothiazole-based small molecule allosteric inhibitor of hACE2, w...
ORGANISM(S): Homo sapiens (Human) Sarbecovirus 
2026-05-01 | PXD075140 | Pride
Human Mb-32 Entry inhibtor Angiotensin-converting enzyme 2 Covid19 Allosteric inhibitor Sarbecovirus Benzothiazole Formaldehyde crosslinking 
ProteomicsSARS-Cov2 coronavirus spike protein-induced apoptosis, inflammatory and oxidative stress responses in THP-1-Like-Macrophages: potential role of angiotensin converting enzyme inhibitor (perindopril)
A purified spike (S) glycoprotein for SARS-COV-2 coronavirus was used to studying its effects on THP-1 macrophages, PBMCs and HUVEC cells. The S protein mediates SARS-CoV-2 entry into cells through binding to angiotensin converting enzyme 2 (ACE2) receptors. We measured viability, intracellular cyto...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2021-11-16 | PXD025516 | Pride
Sars-cov-2 spike protein  monocyte/macrophages  inflammation  angiotensin converting enzyme inhibitor  proteomics 
ProteomicsThe development of a high throughput screening platform using mass spectrometry for the discovery of potential inhibitors against SARS-CoV-2 Omicron Receptor-Binding Domain and human Angiotensin-Converting Enzyme 2 binding interaction from traditional Chinese medicine
The coronavirus disease 2019 (COVID-19) pandemic, initiated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread worldwide. The entry of SARS-CoV-2 into human cells relies on the interaction between the receptor- binding domain (RBD) of the spike protein on the surfac...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-01-13 | MSV000096835 | MassIVE
ProteomicsMDM2 influences ACE2 stability and SARS-Cov2 uptake
The Angiotensin-converting enzyme 2 (ACE2) receptor is the central entry point for SARS-Cov2. Several SAR-Cov2 substrains have developed mutations in their spike protein to maximize their use of ACE2, e.g. to strengthen ACE2 binding for increased uptake or adapt to specific amino acid properties of ...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2023-09-08 | PXD040891 | Pride
Human Ubiquitination Sars-cov2 Ace2 
UnknownMolecules in pathogenesis: angiotensin converting enzyme 2 (ACE2).
Not available
S-EPMC7409947 | biostudies-literature
UnknownAngiotensin-Converting Enzyme-2
Not available
S-EPMC7150073 | biostudies-literature
UnknownDroplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity.
Not available
S-EPMC11792573 | biostudies-literature
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