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GenomicsAge-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG
Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG
PRJNA1098024 | ENA
TranscriptomicsAge-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG
The bipolar disorder (BD) risk gene ANK3 encodes the scaffolding protein AnkyrinG(AnkG). In neurons, AnkG regulates polarity and ion channel clustering at axon initial segments and nodes of Ranvier. Disruption of neuronal AnkG causes BD-like phenotypes in mice. During development, AnkG is also expre...
ORGANISM(S): Mus musculus 
2024-04-12 | GSE263546 | GEO
UnknownAge-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG.
Not available
S-EPMC11686269 | biostudies-literature
UnknownAn evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels.
Not available
S-EPMC11289519 | biostudies-literature
UnknownOverrepresentation of genetic variation in the AnkyrinG interactome is related to a range of neurodevelopmental disorders.
Not available
S-EPMC7785003 | biostudies-literature
UnknownbetaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG.
Not available
S-EPMC2063985 | biostudies-literature
UnknownAnkyrinG is required to maintain axo-dendritic polarity in vivo.
Not available
S-EPMC2765162 | biostudies-literature
ProteomicsImmunoproximity biotinylation reveals the axon initial segment proteome
The axon initial segment (AIS) is a specialized neuronal compartment required for action potential generation and neuronal polarity. However, understanding the mechanisms regulating AIS structure and function has been hindered by an incomplete knowledge of its molecular composition. Here, using immu...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-02 | PXD045921 | Pride
Axon initial segment Neuron Proteomics Proximity labeling Scrib Ankyring 
UnknownLoss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment.
Not available
S-EPMC6349729 | biostudies-literature
GenomicsOverrepresentation of genetic variation in the AnkyrinG interactome is related to a range of neurological disorders
Upon the discovery of numerous genes involved in the pathogenesis of neurodevelopmental disorders, several studies showed that a significant proportion of these genes converge on common pathways and protein networks. Here, we used a reversed approach, by screening the well-characterized AnkyrinG pr...
EGAS00001004326 | EGA
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