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GenomicsThe diphenylpyrazol compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
The diphenylpyrazol compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
PRJNA412589 | ENA
TranscriptomicsThe diphenylpyrazol compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Alzheimer’s disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse mode...
ORGANISM(S): Mus musculus 
2017-09-30 | GSE104424 | GEO
UnknownMechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b.
Not available
S-EPMC10012450 | biostudies-literature
UnknownSynthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation.
Not available
S-EPMC10221781 | biostudies-literature
ProteomicsInterfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins
Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically disordered protein α-synuclein is upregulated to high levels; and while toxic to dopaminergic neurons in Parkinson’s disease, it is highly beneficial for primary and metastatic me...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-07-03 | PXD030615 | Pride
Mhc Xenograft Melanoma Anle138b 
UnknownTherapeutic Trial of anle138b in Mouse Models of Genetic Prion Disease.
Not available
S-EPMC9973041 | biostudies-literature
UnknownReducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Not available
S-EPMC4612332 | biostudies-literature
UnknownThe clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils.
Not available
S-EPMC9474542 | biostudies-literature
UnknownThe diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Not available
S-EPMC5760857 | biostudies-literature
UnknownAnle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy.
Not available
S-EPMC6492169 | biostudies-literature
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