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MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
TranscriptomicsAIR100 SysBio Approach
Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to study normal biological processes and lung disease mechanisms, to develop new therapies, and to assess the biological perturbations induced by environmental pollutants. Herein, we further develop this in v...
ORGANISM(S): Homo sapiens 
2012-04-01 | E-MTAB-874 | biostudies-arrayexpress
MetabolomicsChronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study: Serum Lipidomics
The overall clinical study used a parallel-group, case-controlled study design in order to identify a biomarker or panel of biomarkers for the differentiation of subjects with mild to moderate COPD (GOLD stage I and II), asymptomatic current smokers, former smokers and never-smokers and to compare p...
2017-02-20 | MTBLS358 | MetaboLights
Transcriptomics28d Rat Inhalation Study
We have performed a 28 days rat inhalation study according to the OECD TG 412 by exposing rats for 28 days to filtered air (sham), or to a low, medium, or high concentration of mainstream (MS) cigarette smoke (CS) from the Reference cigarette 3R4F in addition to MS CS from a prototypic modified risk...
ORGANISM(S): Rattus norvegicus 
2014-05-30 | E-MTAB-1842 | biostudies-arrayexpress
TranscriptomicsModulation of atherogenic lipidome
Objective: Although relationships between smoking and cardiovascular diseases (CVD), and CVD and lipids are established, direct impact of cigarette smoke (CS) on lipidomes remains elusive. We investigated the effect of 6 month smoke exposure on a well-established mouse model for human atherogenesis,...
ORGANISM(S): Mus musculus 
2013-10-03 | E-MTAB-1195 | biostudies-arrayexpress
TranscriptomicsPlatform Comparison for miRNA
The goal of this study was to investigate the generation and normalization of microRNA expression data based on microarray technologies to comparatively assess their quality. Two profiling platforms were compared: the single-channel Affymetrix GeneChip(r) and the Exiqon dual-channel miRCURY LNA(tm),...
ORGANISM(S): Mus musculus 
2012-04-01 | E-MTAB-875 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of prostate cancer cell line PC-3 ectopically expressing miR-34c to identify genes regulated by this microRNA
In this study we set out to characterize the mechanisms by which miR-34c deregulation contribute to PCa progression. The genes regulated by miR-34c in the prostate cancer cell line PC3 were identified by microarray analyses, and the top biofunctional pathways enriched for identified genes were found...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-41322 | biostudies-arrayexpress
TranscriptomicsEffect of cessation after initial exposure to cigarette smoke
Although smoking cessation shows clear cardiovascular risk benefits, lung-related disease risk remains higher in former smokers than in never smokers. To better understand the factors involved in this phenomenon, ApoE-/- mice were exposed to mainstream cigarette smoke (CS) or a smoking cessation-mim...
ORGANISM(S): Mus musculus 
2013-10-19 | E-MTAB-1390 | biostudies-arrayexpress
TranscriptomicsIN VITRO ASSESSMENT OF ACUTE EXPOSURE OF THS2.2 AEROSOL ON ORGANOTYPIC ACUTE HUMAN ORAL TISSUE CULTURES
Besides its well-known effects increasing predisposition to oral cancer, cigarette smoke (CS) exposure is an important risk factor for many conditions including periodontal diseases, gingivitis and other benign mucosal disorders. Smoking cessation remains the most effective approach for minimizing r...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-MTAB-4742 | biostudies-arrayexpress
TranscriptomicsIn-Vitro Cell Adhesion Assay
Cigarette smoke (CS) has been reported to affect the adhesion of monocytes to endothelial cells, a critical step in atherogenesis. Using an in vitro adhesion assay together with innovative computational systems biology approaches to analyze omics data, our study aimed at investigating CS-induced mec...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-MTAB-3644 | biostudies-arrayexpress
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