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Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
TranscriptomicsRNA profiling of the dorsal root ganglia, spinal cord, and anterior cingulate cortex in mice with CFA-induced inflammatory pain
To investigate the molecular mechanisms underlying pain and emotion - related responses in the nervous system, this experiment focused on dorsal root ganglia (DRG), spinal cord (SC), and anterior cingulate cortex (ACC) tissues. Mice were divided into sham and complete Freund's adjuvant (CFA) - induc...
ORGANISM(S): Mus musculus 
2026-08-30 | E-MTAB-15797 | biostudies-arrayexpress
GenomicsBulk-tissue RNA-sequencing of anterior cingulate cortex samples derived from Lewy body disease patients
Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping neurodegenerative diseases collectively known as the Lewy body diseases (LBDs). A variety of molecular mechanisms have...
EGAS00001005305 | EGA
ProteomicsProtein degradation targets in the anterior cingulate cortex during indirect fear conditioning
This project examined sex differences in the role of K48 polyubiquitination in the prefrontal cortex during the indirect acquisition (observing another animal undergo fear conditioning) of an auditory fear memory formation in male and female rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2024-12-02 | PXD046274 | Pride
Anterior cingulate cortex Sex differences Ubiquitin Ptsd K48 
ProteomicsIdentification of Novel Biomolecular Characteristics and Bioinformatic Analyses of the Anterior Cingulate Cortex in Morphine-Dependent Mice via Proteomic Profiling
Impaired function of the anterior cingulate cortex (ACC) is widely recognized as a critical factor in drug dependence. This study aimed to investigate protein alterations in the ACC of morphine-dependent mice using 4D label-free quantitative proteomics. Procrustes analysis and Pearson correlation an...
ORGANISM(S): Mus Musculus 
2025-12-05 | PXD071619 |
TranscriptomicsExpression profiling in dopaminergic brain structures of rats self-administering cocaine
Gene expression profiling in dopaminergic brain structures of rats self-administering cocaine. Effect of histone deacetylase inhibition We have shown that injection of the HDAC inhibitor trichostatin A (TsA) to rats is sufficient to decrease their motivation to self-administer cocaine. The aim of th...
ORGANISM(S): Rattus norvegicus 
2010-01-21 | E-GEOD-18055 | biostudies-arrayexpress
GenomicsNext-generation sequencing of anterior cingulate cortex neurons in a social problem setting in rats
Next-generation sequencing of anterior cingulate cortex neurons in a social problem setting in rats
PRJNA643543 | ENA
GenomicsAnterior cingulate cortex mediates the comorbidity between colorectal cancer and depression-like behaviors
Anterior cingulate cortex mediates the comorbidity between colorectal cancer and depression-like behaviors
PRJNA1185799 | ENA
ProteomicsPTSD mouse anterior cingulate cortex proteome
Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder. Several studies have attempted to characterize molecular alterations associated with PTSD, but most findings were limited to the investigation of specific cellular markers in the periphery or defined brain regions. In the curr...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-17 | PXD002271 | Pride
Ptsd Lc-msms Brain Mouse 
GenomicsA Transcriptomic Analysis of Neuropathic Pain in the Anterior Cingulate Cortex after Nerve Injury
A Transcriptomic Analysis of Neuropathic Pain in the Anterior Cingulate Cortex after Nerve Injury
PRJNA722201 | ENA
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