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ProteomicsOxonium ion guided analysis of quantitative proteomics data reveals site-specific O-glycosylation of anterior gradient protein 2 (AGR2)
Developments in mass spectrometry (MS)-based analyses of glycoproteins have been important to study changes in glycosylation related to disease. Recently, the characteristic pattern of oxonium ions in glycopeptide fragmentation spectra had been used to assign different sets of glycopeptides. In part...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025805 | Pride
Glycoproteomics  tmt labeling  oxonium ion  lc−ms/ms  o-glycosylation  colorectal cancer  agr2 
ProteomicsSecretome profiling of canine mammary tumor cells reveals AGR2-mediated regulation of protein secretion
Canine mammary tumors (CMTs) in intact female dogs serve as a valuable natural model for understanding human cancers. Our previous findings identified the overexpression of Anterior Gradient 2 (AGR2) in CMT tissues compared to normal mammary glands, highlighting its association with CMT progression....
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-06-16 | PXD047008 | Pride
Canine mammary tumor (cmt) Secretome Label-free quantification Anterior gradient 2 (agr2) 
TranscriptomicsThe protein disulfide isomerase AGR2 is essential for the production of intestinal mucus
Protein disulfide isomerases (PDIs) aid protein folding and assembly by catalyzing formation and shuffling of cysteine disulfide bonds in the endoplasmic reticulum (ER). Many members of the PDI family are expressed in mammals but the roles of specific PDIs in vivo are poorly understood. A recent hom...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-12503 | biostudies-arrayexpress
ProteomicsAnterior Gradient protein 2 is a marker of tumor aggressiveness in breast cancer and favors chemotherapy-induced senescence escape.
Among the different chemotherapies available, genotoxic drugs are widely used. In response to these drugs, particularly doxorubicin, tumor cells can enter into senescence. Chemotherapy-induced senescence (CIS) is a complex response. Long described as a definitive arrest of cell proliferation, we and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028073 | Pride
Chemotherapy Agr2 Senescence 
UnknownControl of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
Not available
S-EPMC6554669 | biostudies-literature
UnknownIdentification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2).
Not available
S-EPMC6007958 | biostudies-literature
ProteomicsIdentification of AGR2 interacting proteins in H1299 cells using SILAC quantification
LC-MS/MS analysis with SILAC quantification to identify proteins interacting with AGR2 protein in H1299 lung cancer cells
ORGANISM(S): Homo sapiens (Human) 
2022-01-03 | PXD012687 | Pride
Anterior gradient protein 2  protein-protein interactions  protein disulfide isomerase  lc-ms  silac 
UnknownAnterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration.
Not available
S-EPMC5072742 | biostudies-literature
ProteomicsIdentification of AGR2 interacting proteins in T47D cells using label-free quantification
LC-MS/MS analysis with label-free quantification to identify proteins interacting with AGR2 protein in T47D breast cancer cells
ORGANISM(S): Homo sapiens (Human) 
2022-01-03 | PXD012690 | Pride
Anterior gradient protein 2  protein-protein interactions  protein disulfide isomerase  lc-ms  label-free quatification 
UnknownOxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2).
Not available
S-EPMC8160981 | biostudies-literature
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