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MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
TranscriptomicsNext Generation Sequencing identifies Cdh11 and Mrc1 as novel translational biomarkers of kidney fibrosis
Chronic kidney disease (CKD) is the gradual, asymptomatic loss of kidney function and current tests only identify it when significant loss has already happened. Using RNA sequencing in a mouse model of folic acid (FA) induced nephropathy, here we report the identification of 10 genes that track kidn...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-65267 | biostudies-arrayexpress
ProteomicsNatural small molecule DP combats liver fibrosis by targeting APOL2
Liver fibrosis is an urgent clinical problem without effective treatment. Herein, we conducted a high-content screening on a natural “privileged” diterpenoid library to identify a potent anti-liver fibrosis lead DP. Leveraging photoaffinity labeling approach, apolipoprotein L2 (APOL2), an ER-rich pr...
ORGANISM(S): Homo sapiens (Human) 
2024-08-13 | PXD047924 | Pride
Apol2 Anti-liver fibrosis Natural small molecule Er stress Hes1 
GenomicsExpression profiling of Prognostic Liver Signature and fibrosis-related genes in clinical fibrotic liver tissue cultured with various anti-fibrotic agents
Expression profiling of Prognostic Liver Signature and fibrosis-related genes in clinical fibrotic liver tissue cultured with various anti-fibrotic agents
PRJNA752380 | ENA
GenomicsA master cistromic circuit governing hepatic fibrogenesis [ChIP-seq]
Liver fibrosis is a reversible wound-healing response to liver injury and hepatic stellate cells (HSCs) are central cellular players that mediate hepatic fibrogenesis. However, the molecular mechanisms that govern this process remain unclear. Here, we reveal a novel cistromic circuit in HSCs compris...
ORGANISM(S): Homo sapiens 
2013-04-29 | E-GEOD-38103 | biostudies-arrayexpress
GenomicsIn vivo anti-FAP CAR T therapy reduces fibrosis and restores liver homeostasis in metabolic dysfunction-associated steatohepatitis
In vivo anti-FAP CAR T therapy reduces fibrosis and restores liver homeostasis in metabolic dysfunction-associated steatohepatitis
PRJNA1333850 | ENA
GenomicsDiscovery of myrsinane diterpenoids from Euphorbia prolifera as a new type of anti-liver fibrosis agents that inhibit PI3K-AKT signaling pathway
Discovery of myrsinane diterpenoids from Euphorbia prolifera as a new type of anti-liver fibrosis agents that inhibit PI3K-AKT signaling pathway
PRJNA1392429 | ENA
UnknownErythropoietin-Modified Mesenchymal Stem Cells Enhance Anti-fibrosis Efficacy in Mouse Liver Fibrosis Model.
Not available
S-EPMC7333789 | biostudies-literature
GenomicsPolycyclic-fused cytochalasins with anti-liver fibrosis activity from the endophytic fungus Trichoderma harzianum [TGF-β1+ DMSO or TGF-β1 + 20 μM 8]
Polycyclic-fused cytochalasins with anti-liver fibrosis activity from the endophytic fungus Trichoderma harzianum [TGF-β1+ DMSO or TGF-β1 + 20 μM 8]
PRJNA1404256 | ENA
GenomicsExpression profiling of prognostic liver signature in clinical fibrotic liver tissues cultured with various anti-fibrotic and chemopreventive agents
Expression profiling of prognostic liver signature in clinical fibrotic liver tissues cultured with various anti-fibrotic and chemopreventive agents
PRJNA754395 | ENA
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