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TranscriptomicsRNA-seq of Pdx1-GFP+ sorted E10.5, wildtype and Hes1-/-. Neurog3-dependent Pancreas Dysgenesis Causes Ectopic Pancreas in Hes1 Mutants
RNA-seq of FACS Sorted E10.5 Pdx1-GFP+ of genotypes wildtype and Hes1-/-. Summary statement The developmental mechanisms that cause ectopic pancreas are poorly understood. We show that aberrant dorsal pancreas morphogenesis in Hes1 mutants leads to ectopic pancreas depending on the pro-endocrine ge...
ORGANISM(S): Mus musculus 
2018-08-20 | E-MTAB-6890 | biostudies-arrayexpress
TranscriptomicsExpression data from Hes1 conditional knock-out NOTCH1-induced leukemias
To formally address the biological activity of Hes1 in vivo, we tested the interaction between oncogenic NOTCH1 and acute Hes1 loss in a retroviral-transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full leuk...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-65863 | biostudies-arrayexpress
TranscriptomicsHes1 and Liver Glucocorticoid Signaling
To investigate the role of HES1 during glucocorticoid signaling in the liver, we employed whole-genome microarray expressions in liver mRNA extracted from control and Hes1-liver knockout male mice (HESKOL) that had been adrenalectomized to remove endogenous glucocorticoids. RNA isolated from the liv...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-52106 | biostudies-arrayexpress
TranscriptomicsHes1 and Glucocorticoid Signaling in Bone Sarcoma Cells
To investigate the role of HES1 during glucocorticoid signaling in bone sarcoma cells (U2OS-GR cells) , we employed whole-genome microarray expressions in mRNA extracted from control U2OS-GR and Hes1-overexpressed U2OS-GR cells. RNA isolated from control U2OS-GR and Hes1-overexpressed U2OS-GR cells...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-52727 | biostudies-arrayexpress
TranscriptomicsGene expression alteration in chondrocyte by HES1 overexpression
To investigate target molecules of HES1, we transduced GFP or HES1 into mouse chondrocyte cell line ATDC5, and performed the microarray analysis. HES1 overexpression increased inflammation-related genes including Il6 and Il1rl1. We established stable ATDC5 cells overexpressing GFP or HES1 by lentivi...
ORGANISM(S): Mus musculus 
2015-03-02 | E-GEOD-60737 | biostudies-arrayexpress
GenomicsHES1 ChIP-seq in human embryonic stem cell derived pancreas progenitors Day 13.
To identify genome-wide, direct targets of HES1 in human pancreas progenitors, we performed Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) of endogenous HES1 in the HUES4 PDX1GFP/+ reporter cell line on Day 13 of differentiation from both unsorted bulk populations and FACS-sort...
ORGANISM(S): Homo sapiens 
2022-02-27 | E-MTAB-6922 | biostudies-arrayexpress
TranscriptomicsNotch/HES1-mediated PARP1 activation: A cell-type specific mechanism for tumor suppression
Notch signaling plays both oncogenic and tumor suppressor roles, depending on cell type. In contrast to T cell acute lymphoblastic leukemia (T-ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B-ALL leads to growth arrest and apoptosis. The Notch target Hairy/Enha...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-26366 | biostudies-arrayexpress
TranscriptomicsExpression analysis of common myeloid progenitors (CMPs) expressing Hes1
High levels of Hes1 expression are frequently found in BCR-ABL-positive chronic myelogenous leukemia in blast crisis (CML-BC). In mouse bone marrow transplantation (BMT) models, co-expression of BCR-ABL and Hes1 induces CML-BC–like disease; however the underlying mechanism remained elusive. Here, ba...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-56921 | biostudies-arrayexpress
GenomicsGenome-wide maps of HES1 binding-site in human chondrogenic cell.
Notch signaling modulates skeletal formation and osteoarthritis (OA) development through induction of catabolic factors. Here we examined functional roles of Hes1, the representative downstream transcription factor of Notch signaling, during these processes. Chromatin immunoprecipitation-sequencing...
ORGANISM(S): Homo sapiens 
2014-08-02 | E-GEOD-60006 | biostudies-arrayexpress
GenomicsChIPseq to profile CDK9 and Hes1 occupancy in bone marrow-derived macrophages from C57BL/6 mice
We characterized the CDK9 and Hes1 occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs BMDMs were left untreated or stimulated with LPS for 1 hour. CDK9 or Hes1 ChIP was performed and the DNA products were subject to ChIPseq
ORGANISM(S): Mus musculus 
2016-06-13 | E-GEOD-77334 | biostudies-arrayexpress
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