Sort   by:  
 Page size 
ProteomicsA natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2 (APOL2)-mediated endoplasmic reticulum (ER) stress
To investigate the functional role of APOL2 in liver fibrosis, we performed an unbiased immunoprecipitation-mass spectrometry (IP-MS) analysis for APOL2 in the TGF-β1-stimulated LX-2 cell lysates.
ORGANISM(S): Homo sapiens (Human) 
2024-08-13 | PXD047815 | Pride
Apol2 Anti-liver fibrosis Natural small molecule Er stress Hes1 
ProteomicsNatural small molecule DP combats liver fibrosis by targeting APOL2
Liver fibrosis is an urgent clinical problem without effective treatment. Herein, we conducted a high-content screening on a natural “privileged” diterpenoid library to identify a potent anti-liver fibrosis lead DP. Leveraging photoaffinity labeling approach, apolipoprotein L2 (APOL2), an ER-rich pr...
ORGANISM(S): Homo sapiens (Human) 
2024-08-13 | PXD047924 | Pride
Apol2 Anti-liver fibrosis Natural small molecule Er stress Hes1 
UnknownAPOL2 Stabilizes Ku80 to Confer NHEJ-Mediated Radioresistance in Gastric Cancer.
Not available
S-EPMC12667481 | biostudies-literature
UnknownEpigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2.
Not available
S-EPMC6901591 | biostudies-literature
UnknownStructures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif.
Not available
S-EPMC8316464 | biostudies-literature
TranscriptomicsA natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2
Liver fibrosis is an urgent clinical problem without effective treatment. Herein, we conduct a high-content screening on a natural “privileged” diterpenoid library to identify a potent anti-liver fibrosis lead DP. Leveraging photoaffinity labeling approach, apolipoprotein L2 (APOL2), an ER-rich prot...
ORGANISM(S): Homo sapiens 
2023-12-17 | GSE250087 | GEO
UnknownApolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein.
Not available
S-EPMC4611713 | biostudies-literature
ProteomicsA Circulating Antibody Panel for Pre-transplant Prediction of FSGS Recurrence after Kidney Transplantation
Recurrence of focal segmental glomerulosclerosis (rFSGS) after kidney transplantation is a cause of early and accelerated graft loss. Immuneadsorption can alleviate renal dysfunction and suggests that circulating antibodies (Ab) are likely implicated in disease pathogenesis. To evaluate pathogenic A...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-57099 | biostudies-arrayexpress
GenomicsA natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2
A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2
PRJNA1052009 | ENA
TranscriptomicsIntegrative genomics identifies novel associations with APOL1 risk genotype in African American NEPTUNE subjects
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series. This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-68127 | biostudies-arrayexpress
Sort   by:  
 Page size