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GenomicsTranscriptional mechanisms of resistance to anti-PD-1 therapy
Purpose: To explore factors associated with response and resistance to anti-PD-1 therapy, we analyzed multiple disease sites at autopsy in a patient with widely metastatic melanoma who had a heterogeneous response.Materials and Methods: Twenty-six melanoma specimens (four pre-mortem, 22 post-morte...
EGAS00001002195 | EGA
ProteomicsMFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
To elucidate which secreted factors in tumor tissues (TTs) are responsible for the upregulation of UBE4A as the tumor progresses, we inoculated tumors in mice and analyzed the 2- and 4-week TT fluid by mass spectrometry (MS). By combining molecular weight cut off(MWCO) and the identification of secr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058079 | Pride
Anti-pd-1-therapy resistance Ube4a Extracellular vesicles Mfge8 Pd-l1 
ProteomicsMFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
To identify which E3 ligases ubiquitinate PD-L1, we overexpressed PD-L1-Flag in HEK293 cells and used anti-Flag magnetic beads to pull down PD-L1 from cell lysates. The interacting proteins were then analyzed by mass spectrometry, revealing that three E3 ligases interact with PD-L1.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057691 | Pride
Anti-pd-1-therapy resistance Ube4a Extracellular vesicles Mfge8 Pd-l1 
GenomicsTumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy. [RNA-Seq]
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy. [RNA-Seq]
PRJNA677942 | ENA
GenomicsCancer-induced nerve injury promotes resistance to anti-PD-1 therapy [Spatial Transcriptomics]
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy [Spatial Transcriptomics]
PRJNA1224436 | ENA
GenomicsCancer-induced nerve injury promotes resistance to anti-PD-1 therapy [scRNA-seq]
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy [scRNA-seq]
PRJNA1236846 | ENA
GenomicsCancer-induced nerve injury promotes resistance to anti-PD-1 therapy [RNA-Seq FFPE]
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy [RNA-Seq FFPE]
PRJNA1224435 | ENA
GenomicsCDK4/6 inhibitors reverse primary resistance to anti-PD-1 therapy in LKB1-deficient lung adenocarcinoma
CDK4/6 inhibitors reverse primary resistance to anti-PD-1 therapy in LKB1-deficient lung adenocarcinoma
PRJNA755337 | ENA
GenomicsCancer-induced nerve injury promotes resistance to anti-PD-1 therapy [RNA-seq]
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy [RNA-seq]
PRJNA1236847 | ENA
GenomicsCancer-induced nerve injury promotes resistance to anti-PD-1 therapy [RNA-Seq - cell line]
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy [RNA-Seq - cell line]
PRJNA1224437 | ENA
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