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GenomicsUbe4a liver-specific knockout effect on fasted liver
Ube4a liver-specific knockout effect on fasted liver
PRJNA1109779 | ENA
TranscriptomicsUbe4a liver-specific knockout effect on fasted liver
Ectopic deposition of free fatty acids (FFAs) causes lipotoxicity in metabolic disorders such as obesity/diabetes. How intracellular FFAs are sensed and detoxified remains unclear. We identify a cytosol-facing FA-sensing machinery that synchronizes lipid droplet (LD) dynamics with FFA abundance. Spe...
ORGANISM(S): Mus musculus 
2025-12-31 | GSE267113 | GEO
UnknownUbe4A maintains metabolic homeostasis and facilitates insulin signaling in vivo.
Not available
S-EPMC10368927 | biostudies-literature
UnknownPTBP3 modulates P53 expression and promotes colorectal cancer cell proliferation by maintaining UBE4A mRNA stability.
Not available
S-EPMC8826374 | biostudies-literature
UnknownLoss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid Handling.
Not available
S-EPMC12773002 | biostudies-literature
ProteomicsMFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
To elucidate which secreted factors in tumor tissues (TTs) are responsible for the upregulation of UBE4A as the tumor progresses, we inoculated tumors in mice and analyzed the 2- and 4-week TT fluid by mass spectrometry (MS). By combining molecular weight cut off(MWCO) and the identification of secr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058079 | Pride
Anti-pd-1-therapy resistance Ube4a Extracellular vesicles Mfge8 Pd-l1 
TranscriptomicsTRIP13 Promotes the Expansion and Immunosuppression of CD4+Foxp3+ Regulatory T Cells by Sustaining HAT1 Stability
There is compelling evidence that TNF preferentially activates and expands CD4+Foxp3+ regulatory T cells (Tregs) through TNFR2. However, the precise mechanisms underlying TNF-TNFR2 pathway-mediated Treg proliferation remain to be fully elucidated. In this study, using RNA-seq profiling of TNFR2+ and...
ORGANISM(S): Mus musculus 
2026-08-01 | GSE305021 | GEO
UnknownMFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1.
Not available
S-EPMC11866489 | biostudies-literature
UnknownQuantitative RT-PCR Gene Evaluation and RNA Interference in the Brown Marmorated Stink Bug.
Not available
S-EPMC4856283 | biostudies-literature
UnknownTRIP13 promotes the expansion and immunosuppression of CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells by sustaining HAT1 stability.
Not available
S-EPMC12804696 | biostudies-literature
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