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MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
ProteomicsRetron Eco2 breaks tRNAs for anti-phage defense
Retrons mediate bacterial anti-phage defense by reverse transcribing non-coding RNA into multicopy single-stranded DNA (msDNA). Our study reveals the unique trimeric nucleoprotein structure of Eco2, which solely relies on a single protein for defense, unlike most other retrons. This structure suppor...
ORGANISM(S): Escherichia coli 
2026-02-03 | PXD060313 | Pride
Retron Cryo-em Hdx-ms Anti-phage defense 
ProteomicsA family of lanthipeptides with anti-phage function
Bacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some natural products protect bacteria from phages, the prevalence and diversity of chemical anti-phage defenses remain largely unexplored. Here, we identify ...
ORGANISM(S): Streptomyces albidoflavus 
2026-07-21 | PXD078908 | Pride
Biosynthetic gene clusters Lanthipeptide Actinobacteria Anti-phage defense Natural products 
GenomicsNuclease-NTPase systems use shared molecular features to control bacterial anti-phage defense
Nuclease-NTPase systems use shared molecular features to control bacterial anti-phage defense
PRJNA1294728 | ENA
GenomicsStructural mechanism of the Retron-Eco7 anti-phage defense system
Structural mechanism of the Retron-Eco7 anti-phage defense system
PRJNA1244356 | ENA
GenomicsPhage homing endonuclease amplifies anti-defense genes to evade bacterial immunity [tRF-seq]
Phage homing endonuclease amplifies anti-defense genes to evade bacterial immunity [tRF-seq]
PRJNA1293343 | ENA
GenomicsPhage homing endonuclease amplifies anti-defense genes to evade bacterial immunity [SITE-seq]
Phage homing endonuclease amplifies anti-defense genes to evade bacterial immunity [SITE-seq]
PRJNA1398346 | ENA
OtherNuclease-NTPase systems use shared molecular features to control bacterial anti-phage defense
Bacteria encode diverse defense systems including restriction-modification and CRISPR-Cas that cleave nucleic acid to protect against phage infection. Bioinformatic analyses demonstrate many recently identified anti-phage defense operons are comprised of a nuclease and NTPase protein, suggesting add...
ORGANISM(S): Pseudomonas aeruginosa Bacillus toyonensis Escherichia coli Bacillus massilioanorexius 
2026-02-18 | GSE303276 | GEO
GenomicsStructural mechanism of the Retron-Eco7 anti-phage defense system
Retrons are prokaryotic genetic elements involved in anti-phage defense and consist of a non-coding RNA, a reverse transcriptase (RT), and various effector proteins. Retron-Eco7 (previously known as Retron-Ec78) from Escherichia coli encodes two effector proteins (a PtuA ATPase and a PtuB nuclease) ...
ORGANISM(S): Escherichia coli str. K-12 substr. DH10B 
2025-10-23 | GSE293394 | GEO
OtherPhage homing endonuclease amplifies anti-defense genes to evade bacterial immunity [tRF-seq]
Bacteriophages must overcome diverse bacterial immune systems, yet the molecular principles enabling such escape remain poorly understood. Here, we show that the phage homing endonuclease SegB facilitates immune evasion by promoting the segmental amplification of anti-defense loci. The antiphage def...
ORGANISM(S): Escherichia coli 
2026-02-05 | GSE303005 | GEO
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