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MetabolomicsPyruvate availability governs adaptive antibiotic resistance in Staphylococcus aureus
Adaptive resistance enables bacteria to survive antibiotic stress before stable resistance emerges, yet the metabolic requirements that permit this transitional state remain unclear. Using vancomycin-intermediate Staphylococcus aureus (VISA) evolution as a model, we identify pyruvate availability as...
2026-10-22 | MTBLS16117 | MetaboLights
MetabolomicsUntargeted Metabolomics To Ascertain Antibiotic Modes of Action
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics...
2017-06-16 | MTBLS464 | MetaboLights
MetabolomicsA synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance

The lack of new drugs that are effective against antibiotic-resistant bacteria has caused increasing concern in global public health. Based on this study, we report development of a modified antimicrobial drug through structure-based drug design (SBDD) and modular synthesis. The optimal modified ...

2024-07-03 | MTBLS10516 | MetaboLights
MetabolomicsSmall molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria

We report identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus, whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching those for clinically useful antibiotics. DHB is produced by Ph...

2024-09-06 | MTBLS10720 | MetaboLights
ProteomicsRedox control of antibiotic biosynthesis in Streptomyces formicae
Streptomyces bacteria make diverse specialised metabolites that form the basis of ~55% of clinically used antibiotics. Despite this, only 3% of their encoded specialised metabolites have been matched to molecules and understanding how their biosynthesis is controlled is essential to fully exploit th...
ORGANISM(S): Streptomyces formicae 
2025-08-05 | PXD061171 | Pride
Proteomics Antibiotic biosynthesis Redox Formicamycins Regulation 
MetabolomicsExogenous glutamate potentiates gentamicin to kill multidrug- and carbapenem-resistant Pseudomonas aeruginosa through activating biosynthesis of unsaturated fatty acids

Antibiotic-resistant Pseudomonas aeruginosa is a major clinical challenge due to limited drug uptake. This study shows that exogenous glutamate restores gentamicin efficacy by reprogramming bacterial metabolism to enhance membrane permeability. The effect is mediated through increased biosynthesi...

2025-09-22 | MTBLS12656 | MetaboLights
MetabolomicsRich organic nitrogen impacts clavulanic acid biosynthesis through the arginine metabolic pathway in Streptomyces clavuligerus F613-1

Clavulanic acid (CA) is the preferred clinical drug for the treatment of infections by β-lactam antibiotic-resistant bacteria. CA is produced by Streptomyces clavuligerus, and although there have been many reports on the effects of carbon and nitrogen sources on CA production, the mechan...

2022-12-08 | MTBLS5744 | MetaboLights
TranscriptomicsCross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor
A complex programme of regulation governs gene expression during development of the morphologically and biochemically complex eubacterial genus Streptomyces. Earlier work has suggested a model in which 'higher level' pleiotropic regulators activate 'pathway-specific' regulators located within chromo...
ORGANISM(S): Streptomyces coelicolor 
2006-02-01 | E-GEOD-4138 | biostudies-arrayexpress
ProteomicsPriestia megaterium response to mupirocin treatment
Isoleucyl-tRNA synthetase (IleRS) is an essential enzyme that covalently couples isoleucine to the corresponding tRNA. Bacterial IleRSs group in two clades, ileS1 and ileS2, the latter bringing resistance to the natural antibiotic mupirocin. Generally, bacteria rely on either ileS1 or ileS2 as a sta...
ORGANISM(S): Priestia Megaterium Nbrc 15308 = Atcc 14581 
2022-08-28 | PXD032256 | JPOST Repository
ProteomicsChlorophyll biosynthesis under the control of arginine metabolism
In natural environments, photosynthetic organisms adjust their metabolism to cope with the fluctuating availability of combined nitrogen-sources, a growth limiting factor. For the acclimation, the dynamic degradation/synthesis of tetrapyrrolic pigments as well as of the amino acid arginine is pivota...
ORGANISM(S): Synechocystis Sp. Pcc 6803 (ncbitaxon:1148) 
2023-02-14 | MSV000091280 | MassIVE
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