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MetabolomicsAbsence of tmRNA Increases the Persistence to Cefotaxime and the Intercellular Accumulation of Metabolite GlcNAc in Aeromonas veronii
Bacterial persisters are a small proportion of phenotypically heterogeneous variants with the transient capability to survive in high concentrations of antibiotics, causing recurrent infections in both human and aquatic animals. Transfer-messenger RNA (tmRNA), which was encoded by the ssrA ge...
2021-10-18 | MTBLS1182 | MetaboLights
MetabolomicsAbsence of tmRNA increases the persistence to cefotaxime by upregulating the metabolites GlcNAc in Aeromonas veronii

Bacterial persisters refer to a small proportion of phenotypically heterogeneous variants with transient capability for survival when exposing to high concentrations of antibiotic, which constitute the major cause for recurrent infections both in human and aquatic infections. In pathogenic bacter...

2020-01-10 | MTBLS1191 | MetaboLights
MetabolomicsMacrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli

Mobile colistin resistance (mcr) genes undermine the efficacy of last-line polymyxin antibiotics, and the global prevalence of mcr-3 continues to rise despite reduced colistin use. Here, we show that mcr-3-positive Escherichia coli (E. coli) confers a survival advantage by reprogramming macrophag...

2026-05-30 | MTBLS13550 | MetaboLights
ProteomicsStress response within the host affects antibiotic persistence and treatment outcome in Staphylococcus aureus infections
Staphylococcus aureus can cause severe invasive infections that require prolonged antibiotic treatment. Although S. aureus can easily acquire antibiotic resistance, even fully susceptible bacteria can persist and survive antibiotic therapy, thus complicating treatment. These so-called persisters are...
ORGANISM(S): Staphylococcus aureus 
2021-09-09 | PXD018372 | Pride
Antibiotic persistence 
ProteomicsProteomics Analysis of Evolved Escherichia coli Populations from Cyclic Antibiotic Treatment
When the survivors of antibiotic treatment (persisters) are repeatedly regrown and retreated with the same antibiotic for several cycles, the new population will soon adapt to the treatment condition and become tolerant to the drug. Here, we did evolution experiments on Escherichia coli populations ...
ORGANISM(S): Escherichia coli 
2020-01-10 | PXD013326 | Pride
Proteomics Persistence Antibiotic Persisters Evolved populations 
TranscriptomicsAntibiotic Persistence Emerges from Cell-State-Driven Transcriptional Reprogramming
Antibiotic persistence enables some bacterial cells to survive antibiotic treatment without resistance mutations, contributing to treatment failure and recurrence. The molecular basis of persistence remains unclear due to its transient and heterogeneous nature, which is obscured in bulk analyses. He...
ORGANISM(S): Klebsiella pneumoniae 
2026-05-05 | GSE306416 | GEO
UnknownProteome Dynamics during Antibiotic Persistence and Resuscitation.
Not available
S-EPMC8407246 | biostudies-literature
GenomicsBacterial persistence emerges mainly from antibiotic-specific networks rather than slow growth
Genome-wide Tn-seq analysis of antibiotic persistence in Escherichia coli
PRJEB122537 | ENA
ModelsKaiser2014 - Salmonella persistence after ciprofloxacin treatment
Kaiser2014 - Salmonella persistence after ciprofloxacin treatment The model describes the bacterial tolerance to antibiotics. Using a mouse model for Salmonella diarrhea, the authors have found that bacterial persistence occurs in the presence of the antibiotic ciprofloxacin becaus...
2024-09-02 | BIOMD0000000527 | BioModels
GenomicsPolyphosphate predicts and controls nanoparticle-induced antibiotic persistence
Polyphosphate predicts and controls nanoparticle-induced antibiotic persistence
PRJNA1519915 | ENA
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