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ProteomicsProteomics Study of Filamentous Persisters from Evo3A Evolved Populations during Ampicillin Treatment and Resuscitation
Proteomics is the most suitable tool to study persisters with their complex underlying molecular mechanisms from a system-level perspective, but the number of persisters that present naturally is too few for proteomics analysis. Here, we utilized Evo3A, an evolved population with enriched persisters...
ORGANISM(S): Escherichia coli 
2020-07-13 | PXD016271 | Pride
Antibiotic Resuscitation Β-lactam Proteomics Persisters Ampicillin Filaments 
ProteomicsProteomics Analysis of Escherichia coli Persisters
Persisters, a dormant and multi-drug tolerant subpopulation that are able to resuscitate after antibiotic treatment, have recently received considerable attentions as the major risk of the relapse of various infectious diseases in clinics. However, due to their low abundance and inherent mutability,...
ORGANISM(S): Escherichia coli 
2018-10-16 | PXD010590 | Pride
Tolerant Proteomics Persistence Dormancy Antibiotic 
ProteomicsCharacterization of Metronidazole-tolerant Porphyromonas gingivalis Persisters
This project investigated the phenotypic characteristics of Metronidazole-tolerant Porphyromonas gingivalis persisters, the relevant modulatory effects of hemin and their underlying survival mechanisms. Proteomic analysis was performed to delineate the protein expression profiles of Metronidazole-to...
ORGANISM(S): Porphyromonas gingivalis ATCC 33277 
2018-08-29 | PXD008976 | Pride
Porphyromonas gingivalis Metronidazole Hemin Persisters Lc-ms/ms 
GenomicsIntracellular Staphylococcus aureus persisters upon antibiotic exposure
Intracellular Staphylococcus aureus persisters upon antibiotic exposure
PRJNA586837 | ENA
GenomicsSalmonella persisters undermine host immune defences during antibiotic treatment
Salmonella persisters undermine host immune defences during antibiotic treatment
PRJNA413814 | ENA
TranscriptomicsSalmonella persisters undermine host immune defences during antibiotic treatment
Many bacterial infections are hard to treat and tend to relapse, possibly due to the presence of antibiotic-tolerant persisters that are considered dormant cells when bacteria are grown in laboratory medium. Non-growing persisters also form following uptake of Salmonella by macrophages but their nat...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium Mus musculus 
2018-12-07 | GSE104785 | GEO
TranscriptomicsIntracellular Staphylococcus aureus persisters upon antibiotic exposure
Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state and antibiotic tolerance. Here we provide in vitro evidence of Staphylococcus aureus persisters within infected host cells. We show that the bacteria surviving antibiotic treatment within host cells are pers...
ORGANISM(S): Staphylococcus aureus 
2020-03-25 | GSE139659 | GEO
GenomicsCycling cancer persisters arise from lineages with distinct transcriptional and metabolic programs
Cycling cancer persisters arise from lineages with distinct transcriptional and metabolic programs
PRJNA634136 | ENA
GenomicsHost cholesterol modulates the generation and enrichment of persisters during Mycobacterium tuberculosis infection
Host cholesterol modulates the generation and enrichment of persisters during Mycobacterium tuberculosis infection
PRJNA560771 | ENA
TranscriptomicsCycling cancer persisters arise from lineages with distinct transcriptional and metabolic programs
Non-genetic mechanisms have recently emerged as important drivers of therapy failure in cancer, where some cancer cells can enter a reversible drug-tolerant persister state in response to treatment. While most cancer persisters, like their bacterial counterparts, remain arrested in the presence of d...
ORGANISM(S): Homo sapiens 
2020-05-21 | GSE150949 | GEO
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