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TranscriptomicsTranscriptional Metronidazole treatment
This study aims to search for the effect of 50uM Metronidazole against Entamoeba histolytica and thereby elucidating their mechanism of action
ORGANISM(S): Entamoeba histolytica 
2014-01-14 | E-MTAB-1763 | biostudies-arrayexpress
TranscriptomicsPhenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance
In vitro studies have described metronidazole (MTZ) resistance and the potential mechanisms involved. Costs to fitness and adaptive responses associated with resistance, however, have not been investigated. In this study we generated an HM-1-derived strain resistant to 12 µM MTZ (MTZR). We examined ...
ORGANISM(S): Entamoeba histolytica 
2012-02-22 | E-GEOD-35990 | biostudies-arrayexpress
MetabolomicsThe cecal and fecal metabolomes of horses before and after metronidazole administration
Not available
ORGANISM(S): Equus caballus 
ST001248 | MetabolomicsWorkbench
ProteomicsCharacterization of Metronidazole-tolerant Porphyromonas gingivalis Persisters
This project investigated the phenotypic characteristics of Metronidazole-tolerant Porphyromonas gingivalis persisters, the relevant modulatory effects of hemin and their underlying survival mechanisms. Proteomic analysis was performed to delineate the protein expression profiles of Metronidazole-to...
ORGANISM(S): Porphyromonas gingivalis ATCC 33277 
2018-08-29 | PXD008976 | Pride
Porphyromonas gingivalis Metronidazole Hemin Persisters Lc-ms/ms 
ProteomicsComparative LC-MS analysis of two metronidazole resistant (M1,M2) and one revertant (M1NR) Giardia intestinalis strains with their parental strain (WB-C6)
I this study we analyzed three lines, two of which were created by UV- directed mutagenesis and showed increased levels of metronidazole tolerance (M1 and M2) and the third being a line that reverted spontanously to sensitive after several passages (M1NR) of M1 without metronidazole in the media. On...
ORGANISM(S): Giardia lamblia ATCC 50803 
2022-01-26 | PXD027813 | Pride
Metronidazole resistance Giardia intestinalis Lc-ms 
MetabolomicsNon-targeted metabolomics screen comparing metabolite profiles of serum from PDAC-bearing mice that received metronidazole using high-resolution, high-performance LC-MS/MS analysis.
Not available
ORGANISM(S): Mus musculus 
ST002216 | MetabolomicsWorkbench
ProteomicsProteomic signatures of metronidazole-resistant Trichomonas vaginalis
We conducted iTRAQ-based analysis to profile the proteomes of metronidazole-sensitive (MTZ-S) and MTZ-resistant (MTZ-R) parasites.
ORGANISM(S): Trichomonas vaginalis 
2021-09-09 | PXD018522 | Pride
Trichomonas vaginalis Metronidazole resistance Proteome 
ProteomicsFactors of metronidazole resistance in the human parasite Trichomonas vaginalis
Trichomonas vaginalis is a sexually transmitted human parasite causing trichomoniasis, leading to vaginitis or cervicitis in many patients. Furthermore, infections can lead to premature labour or loss of child as well as an increase in the risk of contracting HIV. For treatment the antibiotic 5-nitr...
ORGANISM(S): Trichomonas vaginalis 
2025-03-10 | PXD051345 | Pride
Trichomonas vaginalis Metronidazole resistance Parasite Sexually transmitted disease Antibiotic resistance Comparative proteomic analysis Lc-ms/ms 
TranscriptomicsTranscriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica
Previously, we have shown that in Entamoeba histolytica, methionine γ-lyase (EhMGL) downregulation results in trifluoromethionine resistance. The transcriptional response, however, of this parasite to the drug is not known. In this study, we used microarray analysis to determine if additional genes ...
ORGANISM(S): Entamoeba histolytica 
2011-11-16 | E-GEOD-32314 | biostudies-arrayexpress
GenomicsMetronidazole resistance in Clostridioides difficile.
Emergence of high-level and stable metronidazole resistance in Clostridioides difficile.
PRJEB37089 | ENA
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