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TranscriptomicsHemin and iron transcriptome of Porphyromonas gingivalis (part 1)
Transcriptional profiling of P. gingivalis cells comparing cells grown under hemin replete conditions to that grown under hemin depleted conditions Two-condition experiment, hemin replete vs. hemin deplete grown cells. Biological replicates: 3 independently grown and harvested bacterial cells. Four ...
ORGANISM(S): Porphyromonas gingivalis 
2015-05-18 | E-GEOD-50701 | biostudies-arrayexpress
TranscriptomicsChange in gene expression in Chlamydomonas reinhardtii upon heat shock and feeding with hemin and Mg-protoporphyrin
This SuperSeries is composed of the following subset Series: GSE20859: Change in gene expression in Chlamydomonas reinhardtii upon heat shock GSE20860: Change in gene expression in Chlamydomonas reinhardtii upon feeding with hemin and Mg-protoporphyrin Refer to individual Series
ORGANISM(S): Chlamydomonas reinhardtii 
2011-03-11 | E-GEOD-20861 | biostudies-arrayexpress
ProteomicsProteomic study of a breast cancer cell line following hemin treatment
Heme, an iron-containing prosthetic group found in many proteins, carries out diverse biological functions such as electron transfer, oxygen storage and enzymatic reactions. Hemin, the oxidised form of heme, is used to treat porphyria and also to activate heme-oxygenase (HO) which catalyses the rate...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD036701 | Pride
Hemin Proteomic Mass spectrometry Breast cancer Heme oxygenase-1 
ProteomicsDepletion Assisted Hemin Affinity (DAsHA) Proteomics Reveals an Expanded Landscape of Heme Binding Proteins in the Human Proteome
Heme b (iron protoporphyrin IX) plays important roles in biology as a metallocofactor and signaling molecule. However, the targets of heme signaling and the network of proteins that mediate the exchange of heme from sites of synthesis or uptake to heme dependent or regulated proteins are poorly unde...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037165 | Pride
Heme Heme trafficking Proteomics Heme binding protein Cell stress Heme affinity Hemin agarose Labile heme pool 
TranscriptomicsTranscription profiling timecourse of human K562 cell line exposure to hemin
K562 cells (duplicate cultures A & B) are treated with 50 micromolar hemin for 0, 6, 12, 24, 48, 72 hours followed by RNA extraction and gene expression profiling on Affymetrix human U133A arrays and analysis by MAS 5.0
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-1036 | biostudies-arrayexpress
ProteomicsHow the presence of hemin affects the expression of all iron-uptake pathways in Pseudomonas aeruginosa cells
Iron is an essential nutriment for almost all organisms, but this metal is poorly bioavailable. During infection, bacteria access iron from the host by importing either iron or hemin. Pseudomonas aeruginosa, a Gram-negative pathogen, secretes two siderophores, pyoverdine (PVD) and pyochelin (PCH), t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2022-03-15 | PXD028818 | Pride
Pseudomonas Hemin Iron uptake pathway 
TranscriptomicsTranscriptome Analysis of Renal Ischemia/Reperfusion Injury and its Modulation by Ischemic Pre-Conditioning or Hemin treatment
We examined, through an oligonucleotide microarray protocol, the renal differential transcriptome profiles of mices submitted to IRI, IPC and Hemin treatment. After identifying the profiles of differentially expressed genes observed for each comparison, we carried out functional enrichment analysis ...
ORGANISM(S): Mus musculus 
2012-12-10 | E-GEOD-39548 | biostudies-arrayexpress
TranscriptomicsPorphyromonas gingivalis 33277 wild-type vs Fur orthologue Har isogenic mutant ECR455
Porphyromonas gingivalis is a major pathogen associated with the microbial biofilm-mediated disease chronic periodontitis. P. gingivalis has an obligate requirement for iron and protoporphyrin IX which it satisfies by transporting heme and iron liberated from the human host. The level of cellular ir...
ORGANISM(S): Porphyromonas gingivalis ATCC 33277 
2015-04-01 | E-GEOD-37099 | biostudies-arrayexpress
TranscriptomicsChIP-chip from 48h hemin induced K562 cells with GATA-1, EKLF, and NF-E2 antibodies
The transcription factor GATA-1, EKLF and NF-E2 promotes erythroid differentition by regulating their target genes, however, the intricate interplays between these key TFs and microRNA genes are largely unknown. Chromatin immunoprecipitation (ChIP) of GATA-1, EKLF and NF-E2 together with microRNA ge...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-30808 | biostudies-arrayexpress
ProteomicsHemin- and temperature-dependent proteome alteration of Porphyromonas gingivalis
This study investigated the alteration of P. gingivalis proteome under the combinative conditions of hemin and temperature, revealing perturbation of proteins.
ORGANISM(S): Porphyromonas gingivalis ATCC 33277 Bacteria 
2026-02-21 | PXD057081 | Pride
Porphyromonas gingivalis Hemin Temperature Dda 
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