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MetabolomicsMacrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli

Mobile colistin resistance (mcr) genes undermine the efficacy of last-line polymyxin antibiotics, and the global prevalence of mcr-3 continues to rise despite reduced colistin use. Here, we show that mcr-3-positive Escherichia coli (E. coli) confers a survival advantage by reprogramming macrophag...

2026-05-30 | MTBLS13550 | MetaboLights
GenomicsA novel antibiotic resistance mechanism
A novel antibiotic resistance mechanism
PRJEB25942 | ENA
MetabolomicsNonspecific activities of the major herbicide-resistance gene BAR
Bialaphos resistance (BAR) and phosphinothricin acetyltransferase (PAT) genes, which convey resistance to the broad-spectrum herbicide phosphinothricin (also known as glufosinate) via N-acetylation, have been globally used in basic plant research and genetically engineered crops. Although early in v...
2017-12-05 | MTBLS553 | MetaboLights
ProteomicsABCF Protein-Mediated Resistance Shapes Bacterial Responses Based on Antibiotic Type and Concentration
Antibiotic resistance (ARE) ABCF proteins are widespread, genome-encoded resistance factors in Gram-positive bacteria that rescue ribosomes stalled by antibiotics. In this study, we integrate genetic, proteomic, metabolomic, and biochemical approaches to reveal that ARE5 subfamily proteins, TiaA and...
ORGANISM(S): Streptomyces coelicolor 
2025-07-28 | PXD063714 | Pride
Streptomyces coelicolor Are acbf proteins Antibiotic resistance 
MetabolomicsUntargeted serum metabolomics of early-life antibiotic intervention, fecal microbiota transplantation restoration, and short-term high-fat diet effects in C57BL/6 mice
This study profiles the serum metabolome in C57BL/6 mice subjected to early-life antibiotic treatment (vancomycin and gentamicin, 2 weeks), followed by fecal microbiota transplantation and a short-term high-fat diet. Serum samples were collected longitudinally and analyzed by liquid chromatography-t...
2026-08-20 | MTBLS14801 | MetaboLights
MetabolomicsStress-induced enrichment of Pseudomonas sp. stimulates the adaptive response of Auxenochlorella pyrenoidosa and antibiotic-resistant proliferation

The phycosphere is an important ecological niche for bacteria and antibiotic resistance genes (ARGs). However, whether and how the interaction between microalgae and bacteria changed, and its further effect on the transmission of ARGs under pollutant stress remains enigmatic. Here, Auxenochlorell...

2025-09-26 | MTBLS11371 | MetaboLights
ProteomicsMechanisms of antibiotic resistance to enrofloxacin in uropathogenic Escherichia coli in dog
Escherichia coli (E. coli) urinary tract infections (UTIs) are becoming a serious problem both for pets and humans (zoonosis) due to the close contact and to the increasing resistance to antibiotics. Great progress has been made in the discovery of novel antibiotics to counteract E. coli pathogens. ...
ORGANISM(S): Escherichia coli 
2015-06-05 | PXD002000 | Pride
Escherichia coli Enrofloxacin Antibiotic resistance Urinary tract infections 
ProteomicsSelective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides
Understanding antibiotic resistance is essential for combating drug-resistant pathogens. Many bacteria horizontally acquire enzymes that modify antibiotics or their targets to prevent interaction, but when resistance emerges without such modifications, the underlying mechanisms often remain unknown....
ORGANISM(S): Escherichia coli 
2025-08-28 | PXD061583 | Pride
Proteomics Antibiotic resistance Ribosome Protein synthesis Misreading 
MetabolomicsGlutamate-mediated metabolic rewiring boosts CpxA/R-OmpF porin and proton motive force to resensitize antibiotic-resistant Escherichia coli to ceftazidime

Ceftazidime (CAZ) is a critically important broad-spectrum antibiotic widely used in clinical practice. However, the rapid emergence of bacterial resistance to CAZ poses a significant challenge in treating infections caused by multidrug-resistant pathogens. In this study, we employed a metabolism...

2026-01-20 | MTBLS13732 | MetaboLights
MetabolomicsGlucose potentiates florfenicol killing of antibiotic-resistant V. parahaemolyticus by enhancing proton motive force and reactive oxygen species

 Florfenicol is valued for its clinical safety, particularly its reduced bone marrow toxicity compared to other old antibiotics of chloramphenicols. However, the rise of bacterial resistance threatens its efficacy. To address this, we evolved a florfenicol-resistant strain of Vibrio par...

2025-10-14 | MTBLS13132 | MetaboLights
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