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ProteomicsTranslation Error Clusters Induced by Aminoglycoside Antibiotics
Aminoglycoside antibiotics (AGAs) target the ribosome and induce mistranslation, yet which translation errors induce bacterial cell death is unclear. The analysis of cellular proteins by quantitative mass spectrometry shows that bactericidal AGAs induce not only single translation errors, but also c...
ORGANISM(S): Escherichia coli 
2021-04-06 | PXD019188 | Pride
Antibiotics Miscoding Ribosome Streptomycin Aminoglycoside E. coli Misreading 
GenomicsPhenotype of Mrps5-associated polymorphisms is intimately linked to mitoribosomal misreading
Phenotype of Mrps5-associated polymorphisms is intimately linked to mitoribosomal misreading
PRJNA802128 | ENA
ProteomicsTranslation Error Clusters Induced by Aminoglycoside Antibiotics
Aminoglycoside antibiotics target the ribosome and induce mistranslation, yet which translation errors induce bacterial cell death is unclear. The analysis of cellular proteins by quantitative mass spectrometry shows that bactericidal aminoglycosides induce not only single errors, but also clusters ...
ORGANISM(S): Escherichia coli 
2021-04-06 | PXD022098 | Pride
Aminoglycosides 
TranscriptomicsPhenotype of Mrps5-associated polymorphisms is intimately linked to mitoribosomal misreading
Recently, we have identified a point mutation V338Y in mammalian nuclear-encoded mitochondrial protein MrpS5 that confers error-prone mitochondrial protein synthesis. In-vivo, mutation V338Y was associated with a distinct phenotype including impaired mitochondrial function, enhanced susceptibility t...
ORGANISM(S): Homo sapiens 
2022-04-27 | GSE195772 | GEO
UnknownPhenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.
Not available
S-EPMC9030964 | biostudies-literature
UnknownMitochondrial deafness alleles confer misreading of the genetic code.
Not available
S-EPMC2265171 | biostudies-literature
UnknownCodon-specific effects of tRNA anticodon loop modifications on translational misreading errors in the yeast Saccharomyces cerevisiae.
Not available
S-EPMC6212777 | biostudies-literature
TranscriptomicsBiological effect of chronic mistranslation in mammalian cells
Analysis of HEK293 cells lines expressing mutant ribosomal protein RPS2 (human A226Y). RPS2 A226Y mutation has been shown to cause misreading and readthrough. Results provide insight into the response to chronic mistranslation in mammalian cells.
ORGANISM(S): Homo sapiens 
2019-09-24 | GSE115153 | GEO
UnknownA structural basis for streptomycin-induced misreading of the genetic code.
Not available
S-EPMC3552334 | biostudies-literature
ProteomicsSelective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides
Antibiotic resistance is a growing threat, underscoring the need to understand the underlying mechanisms. Aminoglycosides kill bacteria by disrupting translation fidelity, leading to the synthesis of aberrant proteins. Surprisingly, mutations in fusA, a gene encoding translation elongation factor G ...
ORGANISM(S): Escherichia coli 
2025-09-05 | PXD067947 | Pride
Antibiotics Ribosome Ef-g Translocation Fidelity Antibiotic resistance Protein synthesis Proteome integrity Misreading Translation 
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