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ProteomicsInhibition of fusidic acid resistance through restricting conformational flexibility in domain III of EF-G
HDX-MS was used to study the binding of FusB to EF-G variants.
ORGANISM(S): Staphylococcus aureus 
2025-12-15 | PXD062993 | Pride
Fusb Ef-g 
ProteomicsFusidic acid resistance through changes in the dynamics of EF-G
HDX-MS was used to study the binding of FusB to EF-G
ORGANISM(S): Staphylococcus aureus 
2020-10-15 | PXD017491 | Pride
E coli 
ProteomicsSelective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides
Antibiotic resistance is a growing threat, underscoring the need to understand the underlying mechanisms. Aminoglycosides kill bacteria by disrupting translation fidelity, leading to the synthesis of aberrant proteins. Surprisingly, mutations in fusA, a gene encoding translation elongation factor G ...
ORGANISM(S): Escherichia coli 
2025-09-05 | PXD067947 | Pride
Antibiotics Ribosome Ef-g Translocation Fidelity Antibiotic resistance Protein synthesis Proteome integrity Misreading Translation 
UnknownEF-G Activation by Phosphate Analogs.
Not available
S-EPMC4884529 | biostudies-literature
UnknownEF-Tu and EF-G are activated by allosteric effects.
Not available
S-EPMC5879710 | biostudies-literature
TranscriptomicsModulation of global transcriptional regulatory networks as a strategy for increasing kanamycin resistance of EF-G mutants
Evolve and resequence experiments have provided us a tool to understand bacterial adaptation to antibiotics by the gain of genomic mutations. In our previous work, we used short term evolution to isolate mutants resistant to the ribosome targeting antibiotic kanamycin. We had reported the gain of re...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2016-07-14 | GSE82343 | GEO
UnknownTwo homologous EF-G proteins from Pseudomonas aeruginosa exhibit distinct functions.
Not available
S-EPMC3832671 | biostudies-literature
UnknownTime-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP.
Not available
S-EPMC8668904 | biostudies-literature
UnknownCorrelated conformational events in EF-G and the ribosome regulate translocation.
Not available
S-EPMC2997181 | biostudies-literature
UnknownStructural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation.
Not available
S-EPMC8324841 | biostudies-literature
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