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MetabolomicsEnterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance
Commensal intestinal bacteria play key roles in regulating cells mediating immune tolerance; however, bacterial strains and related metabolites directly involved in this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different ...
2024-08-05 | MTBLS5585 | MetaboLights
TranscriptomicsFitness Landscape of Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms
Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A major outstanding question is the degree to which the biofilm-specific cellular state and its constituent genetic determinants contribute to this hyper-tolerant phenotype. Here, using genome-wide functional...
ORGANISM(S): Pseudomonas aeruginosa 
2011-11-21 | E-GEOD-26142 | biostudies-arrayexpress
MetabolomicsOriginal data of bacterial antibiotic resistance lipidomics
Plasmid-mediated dissemination of mcr genes has severely compromised colistin efficacy, necessitating adjuvants that restore antibacterial potency without exacerbating toxicity. Despite their essential roles in bacterial survival and virulence, metal ion acquisition systems remain underexplored as t...
2026-08-13 | MTBLS15318 | MetaboLights
MetabolomicsMacrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli

Mobile colistin resistance (mcr) genes undermine the efficacy of last-line polymyxin antibiotics, and the global prevalence of mcr-3 continues to rise despite reduced colistin use. Here, we show that mcr-3-positive Escherichia coli (E. coli) confers a survival advantage by reprogramming macrophag...

2026-05-30 | MTBLS13550 | MetaboLights
MetabolomicsUntargeted serum metabolomics of early-life antibiotic intervention, fecal microbiota transplantation restoration, and short-term high-fat diet effects in C57BL/6 mice
This study profiles the serum metabolome in C57BL/6 mice subjected to early-life antibiotic treatment (vancomycin and gentamicin, 2 weeks), followed by fecal microbiota transplantation and a short-term high-fat diet. Serum samples were collected longitudinally and analyzed by liquid chromatography-t...
2026-08-20 | MTBLS14801 | MetaboLights
ModelsTan2012 - Antibiotic Treatment, Inoculum Effect
Tan2012 - Antibiotic Treatment, Inoculum Effect The efficacy of many antibiotics decreases with increasing bacterial density, a phenomenon called the ‘inoculum effect’ (IE). This study reveals that, for ribosome-targeting antibiotics, IE is due to bistable inhibition of bacterial g...
2024-09-02 | BIOMD0000000425 | BioModels
ProteomicsEmhR is an indole-sensing transcriptional regulator responsive for the indole-induced antibiotic tolerance in Pseudomonas fluorescens
Indole is ubiquitously synthesized by plants and bacteria and functions as an inter species signaling molecule to modulate a wide variety of cellular activities. However, it is not clear how the indole signal is perceived and responded by plant growth promoting rhizobacteria (PGPR) at the rhizospher...
ORGANISM(S): Pseudomonas fluorescens F113 
2023-05-04 | PXD016527 | Pride
Efflux pump Antibiotic tolerance Indole 
MetabolomicsMechanisms of Iprovalicarb and Cycluron in Promoting Conjugative Transfer of Antibiotic Resistance Genes and Outer Membrane Vesicle-Mediated Dissemination
Detect pesticide residues in water, manure, and soil from waterfowl farms.
2026-08-07 | MTBLS15288 | MetaboLights
MetabolomicsChilling-induced restructuring of seed-borne endophytes enhances early cold tolerance and microbiome assembly in common vetch
Chilling stress constitutes a major abiotic constraint on plant growth and productivity. Although plants mobilize well-characterized physiological and transcriptional acclimation mechanisms, the integrative roles of root-associated microbiomes and root exudate chemistry in chilling tolerance, partic...
2026-04-21 | MTBLS14339 | MetaboLights
ProteomicsBatR: A novel regulator of antibiotic tolerance in P. aeruginosa biofilms
Pseudomonas aeruginosa is a multidrug-resistant opportunistic human pathogen. Chronic infections are associated with biofilms, conferring resistance to antimicrobial agents and complicating treatment strategies. This study focuses on understanding the role of the uncharacterized gene PA3049, upregul...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2026-06-26 | PXD050997 | Pride
Proteomics Pseudomonas aeruginosa Antibiotic tolerance Biofilms 
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