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MetabolomicsA serum nuclear magnetic resonance-based metabolomic signature of antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely dia...
2017-09-06 | MTBLS356 | MetaboLights
ProteomicsLow Density Lipoprotein Receptor Targeting Chimeras for Membrane Protein Degradation and Enhanced Drug Delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells, among which antibody-drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depend on efficient lysosomal trafficking for activity. However, many tumor antigens exhibit poor interna...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD064642 | Pride
Antibody based degradation 
ProteomicsQuantitative proteomic analysis of targeted degradation following Pep-TAC treatment
Quantitative proteomic analysis raw data for the manuscript entitled “A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy”.
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-01-22 | PXD060051 |
TranscriptomicsAntibody repertoire RNA-seq throughout key stages of mouse B-cell development (pre-B-cells, naive B cells, plasma cells)
We sought to investigate the extent of genetic and antigen-driven predetermination of antibody repertoires throughout B-cell development (pre-B cells, naive B cells, plasma cells). To this end, we used (i) an inbred model organism (mouse, C57BL/6J) to quantify genetic predetermination and (ii) cohor...
ORGANISM(S): Mus musculus 
2017-03-28 | E-MTAB-5349 | biostudies-arrayexpress
UnknownA Cell-Based Internalization and Degradation Assay with an Activatable Fluorescence-Quencher Probe as a Tool for Functional Antibody Screening.
Not available
S-EPMC4512523 | biostudies-literature
TranscriptomicsAntibody detection of translocations (ADOT) in Ewing Sarcoma
We developed a new approach called antibody detection of translocations (ADOT) which combines a transcriptional microarray-based approach with a novel antibody-based detection method to detect translocations in cancer. ADOT allows for the accurate and sensitive identification of translocations and p...
ORGANISM(S): Homo sapiens 
2012-01-31 | E-GEOD-35450 | biostudies-arrayexpress
TranscriptomicsMethod Study
High-throughput sequencing (HTS) of antibody amplicon libraries has become a powerful method in the emerging field of systems immunology. However, numerous sources of bias in HTS workflows may affect antibody repertoire data. A crucial step in antibody amplicon library preparation is the addition of...
ORGANISM(S): Mus musculus 
2014-02-20 | E-MTAB-2226 | biostudies-arrayexpress
TranscriptomicsOrientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons. In mice, six additional sets of c...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-71005 | biostudies-arrayexpress
UnknownAn antidote approach to reduce risk and broaden utility of antibody-based therapeutics.
Not available
S-EPMC5437253 | biostudies-literature
ProteomicsAntibody RING-Mediated Destruction (ARMeD) of endogenous proteins
To understand the cellular function of a gene the encoding DNA or mRNA transcript can be manipulated and the consequences observed. However, these approaches do not have a direct effect on the protein product of the gene, which is either permanently abrogated or depleted at a rate defined by the hal...
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD018113 | Pride
Ring ubiquitin nanobody endogenous degradation 
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