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TranscriptomicsSanguinarine, putative anticancer therapeutic, interacts, modulates and transcripts in the context of chromatin
DNA-binding anticancer agents cause alteration in chromatin structure and dynamics. Here, we report the dynamic interaction of the DNA intercalator and potential anticancer, plant alkaloid, sanguinarine (SGR) with chromatin. Association of SGR with different levels of chromatin structure was found t...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-14777 | biostudies-arrayexpress
TranscriptomicsSanguinarine, putative anticancer therapeutic, interacts,modulates and transcripts in the context of chromatin
DNA binding anticancer agents cause alteration in chromatin structure and dynamics. Here, we report the dynamic interaction of the DNA intercalator and potential anticancer, plant alkaloid, Sanguinarine (SGR) with chromatin. Association of SGR with different levels of chromatin structure was found t...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-14314 | biostudies-arrayexpress
UnknownPrediction of anticancer property of bowsellic acid derivatives by quantitative structure activity relationship analysis and molecular docking study.
Not available
S-EPMC4333623 | biostudies-literature
UnknownAnticancer property of sediment actinomycetes against MCF-7 and MDA-MB-231 cell lines.
Not available
S-EPMC3609251 | biostudies-literature
TranscriptomicsSanguinarine, putative anticancer therapeutic, interacts, modulates and transcripts in the context of chromatin
DNA-binding anticancer agents cause alteration in chromatin structure and dynamics. Here, we report the dynamic interaction of the DNA intercalator and potential anticancer, plant alkaloid, sanguinarine (SGR) with chromatin. Association of SGR with different levels of chromatin structure was found t...
ORGANISM(S): Homo sapiens 
2011-09-12 | GSE14777 | GEO
TranscriptomicsSanguinarine, putative anticancer therapeutic, interacts,modulates and transcripts in the context of chromatin
DNA binding anticancer agents cause alteration in chromatin structure and dynamics. Here, we report the dynamic interaction of the DNA intercalator and potential anticancer, plant alkaloid, Sanguinarine (SGR) with chromatin. Association of SGR with different levels of chromatin structure was found t...
ORGANISM(S): Homo sapiens 
2009-02-28 | GSE14314 | GEO
TranscriptomicsRegulation of stem cell property and drug resistance of cancer cells by targeting transcriptional machinery via inhibition of neddylation
MLN4924, also known as pevonedistat, is a small molecule inhibitor of NEDD8 activating enzyme (NAE), that inhibits the entire neddylation pathway. As the first-in-class neddylation inhibitor, MLN4924 is currently in Phase I/II clinical trials for anticancer application as a single agent or in combin...
ORGANISM(S): Homo sapiens 
2019-09-14 | GSE134190 | GEO
GenomicsRegulation of stem cell property and drug resistance of cancer cells by targeting transcriptional machinery via inhibition of neddylation
Regulation of stem cell property and drug resistance of cancer cells by targeting transcriptional machinery via inhibition of neddylation
PRJNA554253 | ENA
TranscriptomicsAnalysis of gene expression changes in patient-derived gastric cancer cells after anticancer drug treatment or ALDH1A3 knockdown
Tumors consist of heterogeneous cell population, containing cancer cell subpopulations with anticancer drug-resistant property, called “persister” cells. To reveal the character of the persister cells, we analyzed gene expression profile of patient-derived gastric cells and residual cancer cells aft...
ORGANISM(S): Homo sapiens 
2020-04-14 | GSE139331 | GEO
UnknownDiscovery of a new function of curcumin which enhances its anticancer therapeutic potency.
Not available
S-EPMC4967984 | biostudies-literature
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