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TranscriptomicsEpigenetic effects of antidepressants to neuroprotective genes in neuronal cultured cells
Antidepressants are widely used for treatment of depression. Imipramine, a typical antidepressant, is recently known to have an effect to restore the expression of brain-derived neurotrophic factor gene, which is decreased in depressed patients, by increasing histone acetylation. However, it is larg...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-63005 | biostudies-arrayexpress
ProteomicsProteomic analysis of E. coli K-12 MG1655 with the treatment of antidepressants
Proteomics analyses were conducted to reveal bacterial responses towards antidepressants on translational level.
ORGANISM(S): Escherichia coli 
2023-10-24 | PXD033554 | Pride
Multidrug resistance Fitness cost Persistence Reactive oxygen species (ros) Efflux pump Evolution Antibiotic resistance Toxin-antitoxin system Antidepressants 
ProteomicsBacteria proteomics under antidepressants exposure
This project conducted proteomics on A.baylyi ADP1, E. coli K12 and P. putita KT2440 after treated with a few commonly-prescribed antidepressant (duloxetine, sertraline, fluoxetine, bupropion, escitalopram and agomelatine). The results with help to reveal how those antidepressants can promote the tr...
ORGANISM(S): Acinetobacter sp. ADP1 Escherichia coli Pseudomonas putida 
2024-01-26 | PXD028020 | Pride
A.baylyi adp1  e. coli k12  p. putita kt2440  antibiotic resistance genes  conjugation  transformation 
GenomicsSNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants
SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants
PRJNA929492 | ENA
Genomics
Antidepressants Fermentation2
PRJNA792159 | ENA
Genomics
Antidepressants Fermentation
PRJNA792161 | ENA
TranscriptomicsMolecular regulation in the hippocampal dentate gyrus in the onset and treatment of depression
Major depression is a multidimensional disorder highly prevalent in modern society. Although several classes of antidepressants (ADs) are currently available to treat depression, the effectiveness of treatment is still limited, as many patients do not show full remission; thus, there is a need to fi...
ORGANISM(S): Rattus norvegicus 
2015-07-02 | E-GEOD-56028 | biostudies-arrayexpress
TranscriptomicsEpigenetic effects of antidepressants to neuroprotective genes in neuronal cultured cells
Antidepressants are widely used for treatment of depression. Imipramine, a typical antidepressant, is recently known to have an effect to restore the expression of brain-derived neurotrophic factor gene, which is decreased in depressed patients, by increasing histone acetylation. However, it is larg...
ORGANISM(S): Mus musculus 
2015-01-30 | GSE63005 | GEO
TranscriptomicsGene expression profiling of early-activated targets of antidepressants in glia cells
The identification of cell-type-specific and early-activated pharmacological targets of antidepressants might help to implement the search for alternative targets to develop drugs with safer side-effect profiles and faster onset of actions. Glia cells are active partners of neurons and blood vessels...
ORGANISM(S): Rattus norvegicus 
2016-11-16 | GSE89873 | GEO
GenomicsAntidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior
Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior
PRJNA531007 | ENA
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