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MetabolomicsPeroxin Pex8 couples stress responses, antifungal tolerance and virulence regulation in Candida albicans

Candida albicans, a World Health Organization critical-priority fungal pathogen, represents the predominant cause of candidemia. Therapeutic failure is sometimes driven by antifungal tolerance, a phenotype distinct from resistance, whose underlying mechanisms remain incompletely defined....

2026-03-12 | MTBLS13170 | MetaboLights
MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target

Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell ...

2026-03-13 | MTBLS13992 | MetaboLights
MetabolomicsBioinspired Rhamnolipid Protects Wheat Against Zymoseptoria tritici Through Mainly Direct Antifungal Activity and Without Major Impact on Leaf Physiology

Rhamnolipids (RLs), glycolipids biosynthesized by the Pseudomonas and Burkholderia genera, are known to display various activities against a wide range of pathogens. Most previous studies on RLs focused on their direct antimicrobial activity, while only a few reports described t...

2022-06-21 | MTBLS4542 | MetaboLights
no omics definedTranscription profiling of Candida albicans biofilm exposed to amphotericin B, fluconazole or two concentrations of caspofungin
30h of growth biofilms in microfermentors were exposed to caspofungin 0.5 µg/ml, caspofungin 5 µg/ml, fluconazole 80 µg/ml or amphotericin B 8 µg/ml. Control and antifungal-exposed biofilms were recovered at t= 0, 30, 60 and 120 min post exposure to antifungal.
ORGANISM(S): Candida albicans 
2010-03-02 | E-MEXP-2436 | biostudies-arrayexpress
MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target
Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell biology ...
2026-04-24 | MTBLS14357 | MetaboLights
TranscriptomicsGene expression response to the antifungal compound sampangine
Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analy...
ORGANISM(S): Candida albicans 
2010-05-26 | E-GEOD-10104 | biostudies-arrayexpress
TranscriptomicsAspergillus fumigatus Af293 response to lactic acid bacteria antifungal activity
The effect of cell free supernatant from the antifungal strain Lactobacillus plantarum 16 on the growth of Aspergillus fumigatus Af293 was assessed. Transcriptome analysis of the genome was performed after ten minutes exposure to antifungal supernatant in order to determine the molecular targets inv...
ORGANISM(S): Aspergillus fumigatus 
2013-08-09 | E-MTAB-1701 | biostudies-arrayexpress
TranscriptomicsIdentification and characterization of potent, broad-spectrum antifungal compounds using a yeast reporter bioassay.
New antifungal drugs are urgently needed due to the currently limited selection, the emergence of drug resistance, and the toxicity of several commonly used drugs. To identify drug leads, we screened small molecules using a Saccharomyces reporter bioassay in which the yeast heterologously expresses...
ORGANISM(S): Candida albicans 
2012-04-30 | E-GEOD-35105 | biostudies-arrayexpress
TranscriptomicsIn depth characterization of the activity of a novel synthetic macrocyclic antifungal compound
The systemic infections by peptogenous fungi member of the genera Candida and Aspergillus represent a serious threat for public health. During previous research we have successfully identified a family of compounds active against different Candida spp. including strains resistant to antifungal drugs...
ORGANISM(S): Candida albicans 
2015-04-01 | E-GEOD-65396 | biostudies-arrayexpress
ProteomicsProteomics reveals that the antifungal activity of fenbendazole against Cryptococcus neoformans requires protein kinases.
Cryptococcus neoformans is responsible for over 100,000 deaths annually, and the treatment of this fungal disease is expensive and not consistently effective. Unveiling new therapeutic avenues is crucial. Previous studies have suggested that the anthelmintic drug fenbendazole is an affordable and n...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2024-05-21 | PXD047041 | Pride
Cryptococcus neoformans  antifungal activity  fenbendazole  proteomics  protein kinases 
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