Sort   by:  
 Page size 
MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
TranscriptomicsP. falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors
Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune responses. PfEMP1 also mediates sequestration of infected ...
ORGANISM(S): Plasmodium falciparum 
2010-05-06 | E-GEOD-17029 | biostudies-arrayexpress
ProteomicsAntibodies to protozoan variable surface antigens induce antigenic variation
The genomes of most protozoa encode families of variant surface antigens, whose mutually exclusive changes in expression allow parasitic microorganisms to evade the host immune response1. It is widely assumed that antigenic variation in protozoan parasites is accomplished by the spontaneous appearan...
ORGANISM(S): Giardia lamblia ATCC 50803 
2023-05-10 | PXD031141 | Pride
Exosomes Microvesicles Giardia Antigenic variation 
TranscriptomicsAntigenic variation in recrudescent Plasmodium chabaudi infection
The aim of this study is to look at antigenic variation in recrudescent Plasmodium chabaudi infections and to identify the genes, if any, which allow the parasite to avoid the acquired immune response during recrudescence. This has been done in collaboration with Jean Langhorne at NIMR whose group p...
ORGANISM(S): Plasmodium chabaudi 
2014-01-21 | E-ERAD-206 | biostudies-arrayexpress
ProteomicsUMSBP2 is chromatin remodeler that functions in regulation of gene expression and suppression of antigenic variation in trypanosomes
Universal Minicircle Sequence binding proteins (UMSBPs) are CCHC-type zinc-finger proteins that bind the single-stranded G-rich UMS sequence, conserved at the replication origins of minicircles in the kinetoplast DNA, the mitochondrial genome of trypanosomatids. Trypanosoma brucei UMSBP2 has been re...
ORGANISM(S): Trypanosoma brucei 
2023-07-20 | PXD030439 | Pride
Trypanosomes Antigenic variation Gene expression Umsbp Chromatin remodeling 
TranscriptomicsTranscription profiling of wild type, Pfsir2A knock-out and Pfsir2B knock-out Plasmodium falciparum intra-erythrocytic stages
Pfsir2A and Pfsir2B KOs expression profiling in intra-erythrocytic stages
ORGANISM(S): Plasmodium falciparum 
2008-05-01 | E-TABM-438 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of FCR3 P. falciparum parasites phenotypicaly selected for adhesion on CSA or CD36
Comparison of FCR3 P. falciparum parasites phenotypicaly selected for adhesion on CSA or CD36.
ORGANISM(S): Plasmodium falciparum 
2005-12-31 | E-MEXP-319 | biostudies-arrayexpress
ProteomicsGenome maintenance functions of Trypanosoma brucei DNA Polymerase N include telomere association and a role in antigenic variation
Maintenance of genome integrity is critical to guarantee transfer of an intact genome from parent to offspring during cell division. DNA polymerases (Pols) provide roles in both replication of the genome and the repair of a wide range of lesions. Amongst replicative DNA Pols, translesion DNA Pols pl...
ORGANISM(S): Trypanosoma brucei 
2021-09-08 | PXD015648 | Pride
Trypanosomes  vsg 
ProteomicsAbsolute Quantification of Schistosoma mansoni Esophageal Gland Products
Schistosomes are blood-dwelling helminth parasites causing a debilitating disease in the tropics. Major challenges to control the disease persist and vaccines would provide an additional tool, but their development has been problematic. Rhesus macaques can self-cure following schistosome infection, ...
ORGANISM(S): Schistosoma Mansoni 
2019-11-22 | PXD014899 | panorama
UnknownNorovirus GII.4 strain antigenic variation.
Not available
S-EPMC3014165 | biostudies-literature
Sort   by:  
 Page size