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MetabolomicsMolecular Omics Unveils the Antimicrobial Mechanism of UV-LED-Induced Chitosan Composite Film Against Penicillium itali-cum

Penicillium italicum (P. italicum) is a primary pathogen responsible for postharvest decay in citrus fruits, resulting in substantial economic losses. Chitosan and titanium dioxide and silver (CTS&TiO2&Ag) composite film solutions activated by combined UV and LED light represent innovativ...

2026-06-08 | MTBLS14711 | MetaboLights
TranscriptomicsE.coli response to Antimicrobial Arylamides
We treated logarithmically growing cultures of E.coli with a sub-lethal dose of an antimicrobial arylamide compound (PMX 10070) and Polymyxin B sulfate to measure transcriptional responses in an effort to understand mechanism of action Treated samples were assayed at time = 20min and time = 60min af...
ORGANISM(S): Escherichia coli 
2011-08-02 | E-GEOD-31140 | biostudies-arrayexpress
TranscriptomicsA Gram-positive three-component antimicrobial peptide-sensing system
To survive during colonization or infection of the human body, microorganisms must defeat antimicrobial peptides, which represent a key component of innate host defense in phagocytes and on epithelia. However, is not known how the clinically important group of Gram-positive bacteria sense antimicrob...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-26 | E-GEOD-7163 | biostudies-arrayexpress
MetabolomicsThe killing mechanism of teixobactin against methicillin-resistant Staphylococcus aureus (MRSA): An untargeted metabolomics study

The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacteri...

2020-04-30 | MTBLS1569 | MetaboLights
MetabolomicsMetabolomic analysis of the mechanism of action of yerba mate extract on Salmonella Typhimurium
Background: Salmonella Typhimurium is a gram-negative enteropathogen that infects millions worldwide; the rapid emergence of antibiotic resistant strains has heightened the urgency of developing effective treatment for this pathogen. Previous studies have demonstrated that the aqueous extract of yer...
2017-02-16 | MTBLS359 | MetaboLights
TranscriptomicsQuantitative Different Analysis of antimicrobial peptide LL37 expressed in E.coli Top 10 under aerobic and anaerobic condition.
We reported the transcriptional profiles of E.coli expressing antimicrobial peptide LL37 under stress response condition. 4 samples, two groups, one group is under aerobic condition, the other group is under anaerobic condition. One of samples is E.coli which expressed LL37 as induction in each gro...
ORGANISM(S): Escherichia coli 
2013-08-21 | E-GEOD-43408 | biostudies-arrayexpress
TranscriptomicsAntimicrobial mechanism analysis of an oil-in-water micro-emulsion by DNA microarray-mediated transcriptional profiling of Escherichia coli
The DNA microarray was employed in this study to investigate the gene expression profiles of Escherichia coli treated by an oil-in-water (o/w) microemulsion, in order to better understand the antimicrobial mechanism of the microemulsion as a promising food-grade antimicrobial system. 5,440 open read...
ORGANISM(S): Escherichia coli 
2014-01-28 | E-GEOD-50556 | biostudies-arrayexpress
TranscriptomicsInnate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes
We report the profiling of induced mRNA transcripts in two C. elegan replicate populations -- WT (N2) and mutant strain with deficient HLH30. Both strains were fed either OP50 strain of e-coli (normal feed) or S. aureus Examination of infected versus uninfected wildtype and mutant lawns of animals
ORGANISM(S): Caenorhabditis elegans 
2015-06-04 | E-GEOD-57739 | biostudies-arrayexpress
TranscriptomicsMpeR regulation in Neisseria gonorrhoeae (F19) through an iron-responsive mechanism
Previous studies have shown that the MpeR transcriptional regulator produced by Neisseria gonorrhoeae represses expression of mtrF, which encodes a putative inner membrane protein that works with the MtrC-MtrD-MtrE efflux pump to allow gonococci to resist high levels of multiple hydrophobic antimicr...
ORGANISM(S): Neisseria gonorrhoeae 
2012-04-03 | E-GEOD-32717 | biostudies-arrayexpress
TranscriptomicsIdentification of the teixobactin-induced CroRS regulon in Enterococcus faecalis using RNA-seq.
CroRS is a cell envelope stress response two-component system in the bacterial pathogen Enterococcus faecalis. Antimicrobial tolerance is the ability of an organism to survive, but not proliferate, upon antimicrobial challenge, and is a known precursor to the development of antimicrobial resistance....
ORGANISM(S): Enterococcus faecalis 
2023-09-22 | E-MTAB-12526 | biostudies-arrayexpress
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