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ProteomicsComprehensive proteomic study of the antiproliferative activity of a polyphenol-enriched rosemary extract on colon cancer cells using nano-liquid chromatography-Orbitrap MS/MS
A proteomics strategy based on nano-liquid chromatography-tandem mass spectrometry (nano-LC-MS/MS) using an Orbitrap high-resolution mass spectrometer together with stable isotope dimethyl labeling (DML) is applied to quantitatively examine relative changes in the protein fraction of HT-29 human col...
ORGANISM(S): Homo sapiens (Human) 
2016-06-08 | PXD003623 | Pride
Foodomics Mass spectrometry Colon cancer Dimethyl labeling Ht-29 cells Quantitative proteomics Rosemary extract Antiproliferative activity 
TranscriptomicsIdentification of Alpha Interferon-Induced Genes Associated with Antiviral Activity in Daudi Cells and Characterization of IFIT3 as a Novel Antiviral Gene
A novel assay was developed for Daudi cells in which the antiviral (AV) and antiproliferative (AP) activities of interferon (IFN) can be measured simultaneously. Using this novel assay, conditions allowing IFN AV protection but no growth inhibition were identified and selected. Daudi cells were trea...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-GEOD-32517 | biostudies-arrayexpress
TranscriptomicsInterstitial cystitis and antiproliferative factor treatment
Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment. Explanted bladder epithelial cells from patients with interstitial cystitis (IC) have been shown to differ from explanted control cells in several ways, including pr...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-621 | biostudies-arrayexpress
ProteomicsFGF2 antiproliferative stimulus triggers proteomic and transcriptional changes associated with nucleolar disorganization in K-ras-driven mouse tumor cells (Nucleoli TMT)
Chromatin plays a crucial role in the intermediation between cell signaling and gene expression. The nucleolus is sensitive to stress and can orchestrate a chain of cellular events in response to stress signals. Despite being a growth factor, FGF2 has anti-proliferative and tumor-suppressive functio...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-12 | MSV000090518 | MassIVE
TranscriptomicsRole for ISGF3II in the Antiviral Activity of IFN-gamma
Type-I (e.g. IFN-alpha, IFN-beta) and type-II IFNs (IFN-gamma) have antiviral, antiproliferative, and immunomodulatory properties. Both types of IFN signal through the Jak/STAT pathway to elicit antiviral activity, yet IFN-gamma is thought to do so only through STAT1 homodimers while type-I IFNs act...
ORGANISM(S): Homo sapiens 
2011-01-19 | E-GEOD-25113 | biostudies-arrayexpress
UnknownBimodular Antiparallel G-Quadruplex Nanoconstruct with Antiproliferative Activity.
Not available
S-EPMC6803823 | biostudies-literature
ProteomicsThe post-biotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cell
This research explores the antiproliferative effects of short-chain fatty acid (SCFA) salts (magnesium acetate, sodium propionate, and sodium butyrate) on AGS gastric adenocarcinoma cells. Sodium butyrate (NaB) exhibited the most significant inhibitory impact. The study investigated synergistic inte...
ORGANISM(S): Homo sapiens (Human) 
2024-02-21 | PXD048617 | Pride
Gastric cancer Proteomics Postbiotics Sodium butyrate Dexamethasone Synergy 
UnknownHighly Cancer Selective Antiproliferative Activity of Natural Prenylated Flavonoids.
Not available
S-EPMC6278664 | biostudies-literature
TranscriptomicsAntiproliferative and Apoptotic Activities of Sequence-Specific Histone Acetyltransferase Inhibitors
In parallel to monomeric epigenetic regulators, sequence-specific epigenetic regulators represent versatile synthetic dual-target ligands that achieve regulatory control over multi-gene networks. Development of DNA-binding domain (DBD)-HDAC inhibitors and DBD-HAT activators, which result in increase...
ORGANISM(S): Homo sapiens 
2017-06-28 | GSE100466 | GEO
UnknownOptimized synthesis and antiproliferative activity of desTHPdactylolides.
Not available
S-EPMC6008235 | biostudies-literature
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