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MetabolomicsHippophae rhamnoides-Derived Exosome-like Nanovesicles Alleviate Dexamethasone-Induced Sarcopenia by Remodeling Skeletal Muscle Lipid Metabolism
Skeletal muscle atrophy driven by glucocorticoid excess is a clinically relevant contributor to sarcopenia, yet safe and biologically integrated interventions remain limited. Here we report that extracellular exosome-like nanovesicles derived from Hippophae rhamnoides fruits (HR-ELNs) protect agains...
2026-07-17 | MTBLS15070 | MetaboLights
TranscriptomicsFKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance.
Glucocorticoid excess is linked to central obesity, adipose tissue insulin resistance and type 2 diabetes mellitus. The aim of our study was to investigate the effects of dexamethasone on gene expression in human subcutaneous and omental adipose tissue, in order to identify potential novel mechanism...
ORGANISM(S): Homo sapiens 
2014-08-18 | E-GEOD-42902 | biostudies-arrayexpress
TranscriptomicsEffects of dexamethasone on human skeletal muscle and adipose tissue
Context: Glucocorticoids are frequently prescribed drugs with important side-effects such as glucose intolerance and tissue remodelling. Objective: The goal was to explore the molecular basis of the crosstalk between adipose tissue and skeletal muscle during short term glucocorticoid treatment. Des...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-17992 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells treated with interferon gamma and/or dexamethasone
RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-1815 | biostudies-arrayexpress
TranscriptomicsGene expression profile after dexamethasone in chronic lymphocytic leukemia cells according to IGHV/ZAP-70 status
Glucocorticoids are part of the therapeutic armamentarium of chronic lymphocytic leukemia where it has been suggested that cells with unmutated IGHV genes exhibit higher sensitivity. The mechanisms by which glucorticoids are active in CLL are not well elucidated. We used microarrays to detail the gl...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-33135 | biostudies-arrayexpress
TranscriptomicsDexamethasone regulation of mRNAs in astrocytes in vitro
Analysis of mRNA gene expression changes mediated by synthetic GR-agonist dexamethasone in mouse cortical primary astrocyte cultures Total RNA obtained from astrocyte cultures subjected to 0.25, 1, 2, 4, 6, 12, 18, or 24 hours of ~100nM dexamethasone exposure compared to vehicle control astrocyte cu...
ORGANISM(S): Mus musculus 
2014-06-25 | E-GEOD-39272 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression of granulocytes during in vivo G-CSF/dexamethasone mobilization.
Treatment of healthy donors with G-CSF and dexamethasone, results in sufficient number of circulating granulocytes to prepare granulocyte concentrates for clinical purposes. Granulocytes obtained this way demonstrate relatively normal functional behavior combined with a prolonged life span. To study...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-12841 | biostudies-arrayexpress
ProteomicsEffect of LPS and the glucocorticoid dexamethasone on the mouse Bone Marrow Derived Macrophage Proteome
The concentrations and copy number of proteins in the mouse Bone Marrow Derived proteome was determined for control, 10 ng/mL LPS stimulation, and LPS stimulation plus the addition of 100 nM dexamethasone, after an incubation for 24 hours and with four biological replicates for each condition. Over ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD041375 | Pride
Innate immunity Glucocorticoid Macrophage Dexamethasone Mouse Type i interferon 
GenomicsWhole-genome GR binding sites and histone acetylation status in pediatric acute lymphoblastic leukemia patient-derived xenografts following dexamethasone treatment in vivo
Glucocorticoids are critical components of combination chemotherapy regimens in pediatric acute lymphoblastic leukemia (ALL). However, the signaling pathways regulating apoptosis in glucocorticoid-treated lymphoid cells remain unclear. In this study, pediatric ALL patient-derived xenograft inherentl...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-58266 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse double-positive (CD4+CD8+) thymocytes following dexamethasone treatmen
Glucocorticoids play a role in regulation of T lymphocytes homeostasis and development. In particular, glucocorticoid treatment induces massive apoptosis of CD4+CD8+ double positive (DP) thymocytes. This effect is due to many mechanisms, mainly driven by modulation of gene transcription. To find out...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5463 | biostudies-arrayexpress
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