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MetabolomicsMetabolic landscape remodeling in dystrophic muscle through glucocorticoid steroid regimens
Not available
ORGANISM(S): Mus musculus 
ST001256 | MetabolomicsWorkbench
ProteomicsIdentification of candidate circulating glucocorticoid response biomarkers in humans using a proteomic approach
Glucocorticoids used in pharmacological doses for the treatment of a variety of medical conditions, and endogenous glucocorticoid excess – Cushing’s syndrome, may result in several adverse effects, but currently there is no clinically useful biomarker of glucocorticoid activity. A three-phase prote...
ORGANISM(S): Homo sapiens (Human) 
2021-03-14 | PXD019945 | Pride
Pbmc Glucocorticoid Proteomics Dexamethasone Biomarker 
MetabolomicsChanges in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure
Not available
ORGANISM(S): Canis lupus familiaris 
ST001140 | MetabolomicsWorkbench
MetabolomicsDisruption of Zinc homeostasis can impair maternal glucocorticoid metabolism: consequences on the developing fetus
Not available
ORGANISM(S): Rattus norvegicus 
ST000120 | MetabolomicsWorkbench
ProteomicsIdentification of candidate circulating glucocorticoid response biomarkers in humans using a proteomic approach
Context Glucocorticoids used in pharmacological doses for the treatment of a variety of medical conditions, and endogenous glucocorticoid excess – Cushing’s syndrome, may result in several adverse effects, but currently there is no clinically useful biomarker of glucocorticoid activity. Objective T...
ORGANISM(S): Homo Sapiens 
2021-03-15 | PXD019972 | panorama
TranscriptomicsHes1 and Liver Glucocorticoid Signaling
To investigate the role of HES1 during glucocorticoid signaling in the liver, we employed whole-genome microarray expressions in liver mRNA extracted from control and Hes1-liver knockout male mice (HESKOL) that had been adrenalectomized to remove endogenous glucocorticoids. RNA isolated from the liv...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-52106 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Acute Lymphoblastic Leukemia CEM_C1 cells treated with rapamycin identifies rapamycin as a glucocorticoid resistance reversal agent
Drug resistance remains a major obstacle to successful cancer treatment. Here we use a novel approach to identify rapamycin as a glucocorticoid resistance reversal agent. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-5824 | biostudies-arrayexpress
TranscriptomicsHNF4A is required to specify glucocorticoid action in the liver - RNAseq
The glucocorticoid receptor (GR) is a nuclear hormone receptor critical to the regulation of energy metabolism and the inflammatory response. The actions of GR have been shown to be highly dependent on context. Here, we demonstrate the necessity for liver lineage-determining factor hepatocyte nuclea...
ORGANISM(S): Mus musculus 
2021-04-09 | E-MTAB-10247 | biostudies-arrayexpress
TranscriptomicsThe NOD/SCID Xenograft Model Provides Clinically-Relevant Insights into Glucocorticoid-Induced Gene Expression in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia
Introduction. Glucocorticoids are critical drugs used to treat acute lymphoblastic leukemia, and response to glucocorticoids is highly predictive of outcome. Here we report a study evaluating the NOD/SCID xenograft mouse model to investigate glucocorticoid-induced gene expression. Methods. NOD/SCID ...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30392 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation and transcription of mouse liver in the presence or absence of exogenous glucocorticoid to identify direct targets of the glucocorticoid receptor
The purpose of this study was to identify direct targets of the glucocorticoid receptor (GR) using an orthogonal analysis. An expression study of mouse livers in the presence or absence of exogenous glucocorticoid complemented a genome-wide location analysis on chromatin from the same livers. Thes...
ORGANISM(S): Mus musculus 
2007-09-14 | E-CBIL-38 | biostudies-arrayexpress
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