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MetabolomicsUntargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are ...
2017-06-07 | MTBLS459 | MetaboLights
MetabolomicsNano-Kinetic Implant Surface Mediates Osteo-Antibacterial Synergy through Electromagnetic-Mechanical Coupling
This untargeted LC-MS/MS metabolomics study investigates metabolic differences between laboratory reference Staphylococcus aureus and periprosthetic implant-associated Staphylococcus aureus in bacterial suspension samples associated with implant surface lavage. The metabolomics dataset forms part of...
2026-08-28 | MTBLS15301 | MetaboLights
MetabolomicsSearching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory drug, ...
2021-02-08 | MTBLS873 | MetaboLights
TranscriptomicsTranscription profiling of human DU-145, PC-3MM2 cell lines treated with irradiation reveals Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation
Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation
ORGANISM(S): Homo sapiens 
2009-05-13 | E-MEXP-2172 | biostudies-arrayexpress
GenomicsUTI antibiotic-phage synergy study
UTI antibiotic-phage synergy study
PRJEB92194 | ENA
GenomicsUTI antibiotic-phage synergy study EJ
UTI antibiotic-phage synergy study EJ
PRJEB97996 | ENA
TranscriptomicsTranscription profiling of human A540 non small cell carcinoma cell lines reveals synergy between PPARgamma ligands and platinum-based drugs in cancer
PPARγ is a member of the nuclear receptor family for which agonist ligands have anti-growth effects. However, clinical studies using PPARγ ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARγ activation with chemotherapeutic agents in current us...
ORGANISM(S): Homo sapiens 
2009-04-30 | E-GEOD-7035 | biostudies-arrayexpress
GenomicsVariations in daptomycin-beta-lactam synergy and enterococcal species
Variations in daptomycin-beta-lactam synergy and enterococcal species - Daptomycin-ß-lactam synergy depends on enterococcal species and specific mutation
PRJEB31896 | ENA
ProteomicseEF2K activity determines synergy to PI3K and MEK inhibitors in combination in cancer cells
To understand the mechanisms involved in synergy to PI3Ki + MEKi treatment, we performed a global phosphoproteomics analysis in 3 different cancer cell lines treated with a MEK inhibitor (Trametinib) and a PI3K inhibitor (Pictilisib) at 500 nM individually or in combination for one hour.
ORGANISM(S): Homo sapiens (Human) 
2022-04-25 | PXD018873 | Pride
Phosphoproteomics Kinase signalling Cancer Eef2k Biomarkers 
ProteomicsSilver and platinum nanoparticles synergy
In this study, we compared the effects of silver and platinum NPs on the main components of the blood brain barrier model: human cerebral microvascular endothelial cells (hCMEM/D3) and human primary astrocytes under single and co-exposure NP conditions. The co-exposure to two types of NPs synergisti...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD014425 | Pride
Platinum Astrocytes Blood brain barrier Endothelial cells Silver Nanoparticles Synergy Cytotoxicity 
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