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MetabolomicsTraditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma
Carica papaya leaf decoction, an Australian Aboriginal remedy, has been used widely for its healing capabilities against cancer, with numerous anecdotal reports. In this study we investigated its in vitro cytotoxicity on human squamous cell carcinoma cells followed by metabolomic profiling of Carica...
2017-05-04 | MTBLS274 | MetaboLights
MetabolomicsReal-world neonicotinoid mixture exposure reveals synergistic cytotoxicity and divergent pathway vulnerabilities in human cell lines

In this study, five human cell lines (A2780, Chang liver, HEK293T, HeLa, and HepG2) were used as models and exposed to mixtures of neonicotinoids (NEOs) and their metabolites. The mixture concentrations were prepared based on human biomonitoring data to reflect the actual detected levels of NEOs ...

2026-06-22 | MTBLS13896 | MetaboLights
TranscriptomicsDietary heme induces instantaneous oxidative stress but delayed cytotoxicity and compensatory hyperproliferation in mouse colon
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by luminal cytotoxicity and reactive oxygen species. This surface injury is compensated by hyperproliferation and hyperplasia of crypt cells, which was induced by a...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-40671 | biostudies-arrayexpress
ModelsWong2024 - Cytotoxicity Prediction from Human Cell Lines
The authors use a large dataset (>30k) to train an explainable graph-based model to identify potential antibiotics with low cytotoxicity. The model uses a substructure-based approach to explore the chemical space. Using this method, they were able to screen 283 compounds and identify a candidate act...
2024-05-13 | MODEL2405130002 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
ProteomicsGlobal proteomics to study silica nanoparticle-induced cytotoxicity and its mechanisms in HepG2 cells
Silica nanoparticles (SiO2 NPs) are commonly used in medical and pharmaceutical fields. Research into the cytotoxicity and overall proteomic changes occurring during initial exposure to SiO2 NPs is limited. We investigated the mechanism of toxicity in human liver cells according to exposure time [0,...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024206 | Pride
Silica nanoparticles  cytotoxicity  label-free quantification  proteomic analysis  mass spectrometry 
GenomicsNKCLR3 impairs natural killer cell cytotoxicity by epigenetically targeting the Natural Cytotoxicity Triggering Receptor 1 (NCR1) [lncRNA-seq]
NKCLR3 impairs natural killer cell cytotoxicity by epigenetically targeting the Natural Cytotoxicity Triggering Receptor 1 (NCR1) [lncRNA-seq]
PRJNA1202133 | ENA
ProteomicsProteomic response to cytotoxicity of methylglyoxall
Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase system. MG is increased to cytotoxic levels by clinical anticancer drugs, contributing to thei...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD029315 | Pride
Methylglyoxal Cancer chemotherapy Cytotoxicity 
ProteomicsProteomic analysis on the protective effect of eriodictyol on benzo(a)pyrene-induced Caco-2 cytotoxicity
The present study was aimed to evaluate the protective effects of six different polyphenols against benzo(a)pyrene (BaP)-induced cytotoxicity in Caco-2 cells. The results shows that treatment of quinic acid, ferulic acid, homovanillic acid and BaP decreased the cell viability, whereas only co-treatm...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD030049 | Pride
Benzo(a)pyrene Eriodictyol Proteomics Caco-2 cells Cytotoxicity 
GenomicsNKCLR3 impairs natural killer cell cytotoxicity by epigenetically targeting the Natural Cytotoxicity Triggering Receptor 1 (NCR1)
NKCLR3 impairs natural killer cell cytotoxicity by epigenetically targeting the Natural Cytotoxicity Triggering Receptor 1 (NCR1)
PRJNA1200109 | ENA
ProteomicsCo-culture CRISPR screens reveal ATG9A as a regulator to macrophage-mediated cytotoxicity in cancer
This study investigates the role of cancer cell surface proteins in modulating the response of cancer cells to macrophage-induced cytotoxicity. Utilizing two targeted CRISPR screens using OVCAR-8 cell line and a targeted CRISPR library for cancer cell surface proteins, ATG9A was identified as a key ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD053872 | Pride
Atg9a  macrophage-mediated cytotoxicity  crispr screens  cancer cell surface proteins 
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